In this study, Stenius and Lemola used far less of tartrazine (Yellow 5) and aspirin than what a person may normally ingest, and had to overcome chronic medication as well (see NOTES below). Nevertheless, they reported that a significant number of patients responded to both. Click on the picture to see larger and more detail.
QUOTE: “Tests for sensitivity to analgesics and food additives should be conducted as a routine measure in asthmatics, and sensitive patients should be given information on suitable medication and dietary control.”
QUOTE: [discussing their efforts at creating lists of foods without food additives for their patients] “The best solution would obviously be to establish an international agreement on compulsory and complete declaration of contents, and a general restriction on the use of azo-dyes.”
- All patients were maintained on their daily doses of prednisolone (10 mg or less) which means that the tests had to overcome this medication to be “positive.”
- It is not mentioned whether the medication contained food dye in those days, but according to information dated 2010, the 10 mg tablet by Keltman Pharmaceuticals contains no dye.
- The patients were put on a salicylate-free dye-free diet “as far as possible” for 48 hours before testing.
- The maximum test dosage for aspirin was 100 mg –a little more than a single baby aspirin.
- The maximum dosage for Yellow 5 was 10 mg — about 2/3 of the mean and 1/4 of the maximum amounts recognized by the National Academy of Sciences and the FDA in 1979 (Stevens 2013, Table 2).