Ceserani 1978: Tartrazine and prostaglandin-system

Ceserani1978Prostaglandins and Medicine, 1978 Dec;1(6):499-505

The authors discuss the bronchoconstriction caused by tartrazine (Yellow 5) in people who are aspirin-sensitive, as well as its effect on the prostaglandin system of guinea pig lungs.  They found that the dye inhibits formation of both prostaglandins and thromboxane A2 at the cyclooxygenase level – just like aspirin andindomethacin do.

At right is a graph showing the improvement (2) of an aspirin-sensitive patient on a salicylate-free, dye-free diet, and the dramatic worsening (3) after two weeks with the addition of a very small amount of Yellow 5 per day.  Click on the graph to see detail.

MedLine || Full Text || Get Password

This entry was posted in < 1981, Asthma, Diet Studies, Food Dyes, Research Studies. Bookmark the permalink.

Leave a Reply

Your email address will not be published. Required fields are marked *