Li 2021: Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model

Clinical Infectious Diseases, 2021, Aug 18

Post-vaccine myopericarditis (heart inflammation) has been increasingly reported after the Covid-19 mRNA vaccines.  Whether it can be triggered by accidentally injecting the vaccine into a vein rather than into the muscle was unknown.

The authors used three groups of mice, to be injected with saline (control), intramuscular (IM) vaccine injection, or intravenenous (IV) vaccine injection. 

While the group properly injected (IM) lost weight and had higher cytokine levels for a few days, the IV group actually developed “histopathological changes of myopericarditis” which means their heart tissue deteriorated.  It was quite dramatic, including apoptosis (cell death), necrosis (dead tissue) with inflammatory cell infiltration and calcific deposits on the pericardium.  The spike protein made by the vaccine was found in heart cells and other tissues.

This damage continued for two weeks, and was made much worse by a second shot or a third (booster) shot.

Besides the heart, liver cells were also dramatically degenerated in those mice in the IV group.

The authors recommend briefly withdrawing the syringe plunger to exclude blood aspiration in order to reduce the risk of injecting the vaccine into the vein.

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