Bhatt 2018: Tartrazine Induced Neurobiochemical Alterations in Rat Brain Sub- Regions.

Bhatt, Vyas, Singh, John, Soni.   Food and Chemical Toxicology. 113:322-327.Rats were given the ADI (acceptable daily intake) amount of Tartrazine (Yellow 5).

  1. Their body weight was lower.
  2. The brain protein levels in all their brain sub-regions decreased.
  3. Lipid peroxide levels in all their brain sub-regions increased.
  4. Glutathione-S-transferase activity in all brain sub-regions decreased.
  5. Glutathione reductase activity in some areas of the brain decreased.
  6. Glutathione peroxidase activity in all brain sub-regions increased.
  7. MDA levels in all brain sub-regions increased, indicating damage.


  1. Sulfanilic acid (a breakdown product of Yellow 5) can cross the blood-brain-barrier.
  2. Yellow 5 caused severe oxidative stress.

CONCLUSION:  The authors concluded that ADI levels are not safe levels.

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