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Zhang, Chumanevich, Nguyen, … Hofseth. Toxocology Reports. (11) 221-232 We have long suggested that Red 40 (Allura Red) plays a role in behavioral problems, but here is another angle: it appears likely that Red 40 is also involved in the … Continue reading
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Journal of the Brazilian Medical Association: Revista da Associação Médica Brasileira (1992), 2021 Feb;67(2):287-291. Thirty pregnant rats were given either a mix of nine artificial food dyes or nothing (controls) while pregnant. The doses given were the “no observed adverse … Continue reading
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Nutrients, 2023, June 28, 15(13) 2946. This study is intended to determine the long-term (3o and 90 days) exposure to tartrazine (Yellow 5) on humanized (NMRI) mice. The amount used was the equivalent of the human acceptable daily intake (ADI). … Continue reading
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Masone & Chanforan, Computational Biology and Chemistry. 56(2015): 152-158. Five artificial food dyes were compared to their “natural equivalents” in ability to bind to human serum albumin (HSA). Note: In the case of binding to HSA, less is better. The … Continue reading
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Wopara, Adebayo, Umoren, … Wodo. Heliyon, 7. e08454. e-collection, 21 Nov. Don’t let the complex nature of the picture below (or the title above) distress you — what all the fancy words mean is that this study shows that the … Continue reading
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Bradman, Castorina, Thilakaratne, … Miller. International Journal of Environmental Research and Public Health. Aug 5;19(15):9661 The authors estimated exposure of women of child-bearing age and children to artificial food dyes. Even though these were only one-day and two-day estimates, and … Continue reading
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Lamport, Lawton, Merat … Dye. American Journal of Clinical Nutrition. 103: 775-783. The intent of this study, funded by Welch Foods, was to show that grape juice improves driving ability in stressed people (moms of teens). The authors concluded that … Continue reading
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Kumar, Srivastava. Iranian Journal of Environmental Health Science & Engineering. 8(4): 361-366. The plant Trigonella foenum-graecum (Fenugreek ) was exposed to Yellow 6 for three hours. It’s growing tips reacted with precocious movement, disorientation, and scattering. Note: This must be … Continue reading
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Kobylewski & Jacobson. International Journal of Occupational and Environmental Health. 18(3): 220-246. This review of the toxicology of food dyes finds that all nine of the currently approved dyes in the US have health concerns, including cancer, contamination with benzidine … Continue reading
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Reproductive Sciences. 2023 Apr 18. doi: 10.1007/s43032-023-01240-w. Online ahead of print. Karimi, Khodabandeh, Nazari, Dara, Masjedi, Momeni-Moghaddam This study investigates the toxic effects of the food dye Yellow #6 (Sunset Yellow) on rat testicles, and the protective effects of CoQ10. … Continue reading
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Food Additives & Contaminants, Part A Chemistry, Analysis, Control, Exposure & Risk Assessment. 2023 Apr 26;1-12. doi: 10.1080/19440049.2023.2203778. Online ahead of print In Guaratuba-Parana, Brazil, the diet of 323 preschool children aged 2 to 5 years were studied for three … Continue reading
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Kim et al. Appetite. 127: 274-279. More than 16,000 parents in Korea responded to the Korean version of the ADHD rating scale and also to a food questionnaire. The study found that ADHD symptoms are positively associated with higher consumption … Continue reading
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Jo, Bean. Molecular Pharmacology. 80: 247-257. BBG, a variant of Brilliant Blue (Blue 1) is a P2X7 receptor antagonist and is shown to also block neuronal sodium channels. It is the most potent agent yet found that interacts with sodium … Continue reading
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Irwin, Wong, Kwon. Biomacromolecules. 14(1): 264- 274. Amyloid fibrils such as those found in Alzheimer’s disease are thermodynamically very stable, but there is evidence that small molecules like food dyes can remodel them safely. The authors performed a remodeling trial … Continue reading
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Food Technology. 49-56. This is a scientific status summary by the Expert Panel on Food Safety & Nutrition, based on the Survey of Industry on the Use of Food Additives, by the National Academy of Sciences, from 1977. The 1977 … Continue reading
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Gao, Li, Shen, Yin, An, Jin. Journal of Food Science. 76(6): T125-T129. Middle and high Tartrazine (Yellow 5) doses produced learning and memory deficits. Doses are equivalent to 40 and 80 mg/kg for humans, which is far above the ADI. … Continue reading
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Ferreira, Faria, da Silva Ferreira, Soares-Bezerra. International Journal of Food Science. 2016:7548498 Ferreira reviewed what was known about the medical uses of Blue 1. The purinergic system is widespread throughout the brain, nervous system and every other system in the … Continue reading
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Ferrazoli, de Souza, Nascimento, Oliveira-Giacomelli, Schwindt, Britto, Ulrich. Cell Transplantation. 26: 669-677. This paper describes an effect of Blue 1 ofpotential medical benefit in Parkinson’sdisease. Basically, it can be used to suppress a receptor that is over-active and causing damage … Continue reading
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Faraone, Antshel. Child & Adolescent Psychiatric Clinics of North America. 23(4): 965-72 This paper reviews an evidence-based approach to help doctors explain to parents the relative benefits of nonpharmacologic treatments for ADHD. Food dye exclusion is given a “4” in … Continue reading
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Ganeshpurkar, Saluja. Saudi Pharmaceutical Journal. 25, 149-164. This is a comprehensive review of Rutin — a natural-source pharmaceutical that has an almost unbelievable profile of benefits. It is found in many sources, including passion flowers, apples, and buckwheat (kasha). Prevents … Continue reading
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Eagle. Headache. 52(8): 1321. This paper describes how SULT1A enzymes affect dopamine, a neurotransmitter. Yellow 5 (Tartrazine) is one of the items that can inhibit SULT1A (Note: SULT1A is called PST in some studies). Elevated dopamine is generally blamed for … Continue reading
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Eagle. Food and Chemical Toxicology. 40: 2243-2249. This is an overview of how certain compounds affect the enzymes called phenolsulfotransferase (also called PST or SULT1A), and how enzyme inhibition enzyme causes problems such as migraines, heart arrhythmias, or increased blood … Continue reading
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Nutritional Neuroscience. 18(1); 12-21.Doguc, Aylak, Ilhan, Kulac, Gultekin. No adverse effects were seen on spatial working memory in the rats, but there was increased motility and anxiety, and decreased motivation with gender differences. Gender differences suggest an effect on different … Continue reading
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Toxicology Mechanisms & Methods. 20(6):287- 297. Dalal, Poddar. This study investigated a long-term trial of Erythrosine (Red 3) in rats. 10 – 100 mg/kg/day of Red 3 increased plasma corticosterone levels after several days of administration, similar to pargyline, an … Continue reading
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Pharmacology, Biochemistry, and Behavior. 92(2009): 574-582. Dalal, Poddar. Long-term administration of Erythrosine B (Red 3) increased movement in a dose-dependent manner, but Dalal wanted to test a single large dose in vivo. Dalal said Red 3 is known to increase … Continue reading
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Braganza, Galvez, Ozuah. Contemporary Pediatrics. 23(5): 47-49. This paper’s stated purpose was to advise doctors on how to respond to parents asking about diet therapy for ADHD – in particular, the Feingold diet. To support their opinion, Braganza et al … Continue reading
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Bhatt, Vyas, Singh, John, Soni. Food and Chemical Toxicology. 113:322-327.Rats were given the ADI (acceptable daily intake) amount of Tartrazine (Yellow 5). Their body weight was lower. The brain protein levels in all their brain sub-regions decreased. Lipid peroxide … Continue reading
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Bamforth, Jones, Roberts, Coughtrie. Biochemical Pharmacology. 46(10): 1713-1720. Detoxification enzymes provide the means for inactivation, transport and excretion of the xenobiotics including food dyes. Sulfate conjugation is one of the important methods of handling these compounds. Not only are the … Continue reading
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Pediatrics. Jan;83(1):7-17 The authors tested a number of children using what could be called a “stage two Feingold Diet.” The diet used, in other words, eliminated food dyes and several other additives, but did not eliminate salicylate-containing foods such as … Continue reading
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Disease Models and Mechanisms. 7(9): 1101-1109. This paper describes a neurological effect of Blue 1 that may be of medical benefit in treating spinal cord pathology in amyotrophic lateral sclerosis (ALS). The receptor P2X7 is involved in the central nervous … Continue reading
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Toxicology and Applied Pharmacology. 71: 391-397. NOTE: This is not actually a study of Red 3. Rather, the dye, Red 3, is to help develop this testing method, because it is a known excitatory neurotoxin. The relative refractory period is … Continue reading
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Regulatory Toxicology and Pharmacology. 73(3): 914-922. This is a review of food dye toxicity per official EFSA reports and other studies since 2008. Prenatal exposure to mixtures of food dyes can damage spatial working memory, and may affect brain signaling. … Continue reading
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International Journal of Biological Macromolecules. 127: 297-305 Red 40, with hen egg white lysozyme (HEWL), forms amyloid-like aggregates. (A lysozyme is an enzyme in human tears and egg white.) The amyloid fibril formation can be observed by an electron microscope, … Continue reading
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International Journal of Biological Macromolecules. 98: 277-286. This study investigated the interaction of Yellow 5 with the muscle protein myoglobin. The dye interacts with myoglobin protein to form amorphous aggregates at a pH of 2.0 but not at a pH … Continue reading
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Spectrochimica Acta Part A: molecular and Biomolecular Spectroscopy. 15(181(: 116-124. Tartrazine (Yellow 5) interacts with both human and bovine albumin to form amyloid fibrils such as those found in some neurodegenerative diseases such as Alzheimer’s. MedLine || Full Text
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Perceptual and Motor Skills, 52: 307-313. (FDA study) NOTE: The Conners’ scores for the children when they were ON the diet were not given, but it is assumed the children had actually responded to the diet before being tested on … Continue reading
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Cell Host & Microbe, 31, January 11, 2023, pg. 146-157 In spite of the fact that Dr. Fauci has retired as spokesman for the nation about Covid and other diseases, his position listed in this paper is “Office of the … Continue reading
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European Journal of Epidemiology, 2021 Oct;36(10):993-1004 When babies are given their first vaccines, parents are usually advised to give them Tylenol to prevent and/or treat fevers that frequently follow a vaccination. When moms-to-be are urged to get flu shots and/or … Continue reading
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Feingold Successes Do you have a child with serious problems, and have you been unable to find any real solutions? Like many of us, you may have consulted numerous professionals and received nothing more than a label or a prescription. … Continue reading
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Nature Communications, December 2022, 13 : 7617 FD&C Red #40 is also commonly called “Allura Red” as it is referred to in this paper. It is abbreviated as “AR” in this study and in the picture at right. As you … Continue reading
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Capstone for Masters Degree, Walden University, October 2020 This paper explores the connections between autism, everyday toxic exposures such as fluoridated water, and vaccine damage. One important question, in particular, is whether the link may involve a deficiency of the … Continue reading
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Chemical Research in Toxicology, 2021, 34(11), 2319-2330. QUOTE: “There is growing evidence from human and animal studies indicating an association between exposure to synthetic food dyes and adverse neurobehavioral outcomes in children.” The authors developed a way to evaluate the … Continue reading
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BioMed Research International, vol. 2022 (6829409). This is a review of some of the chemicals added to foods to improve shelf-life, color or taste, from the point of view of safety of the newborn. The authors point out that … Continue reading
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Minerva Pediatrics, 2022. July 13 DOI: 10.23736/S2724-52765.22.06932-4 Use of Tylenol (paracetamol or acetaminophen) during pregnancy and early childhood has been considered safe since the 1970s. Parents are urged to use it routinely after vaccination to prevent or control fever. It … Continue reading
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Environmental Health, 2022 Apr 29;21(1):45. Concern that synthetic food dyes may impact behavior in children prompted the California Office of Environmental Health Hazard Assessment (OEHHA) to review the research on both children and animals. 64% of the 25 challenge studies … Continue reading
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Cureus, 2022 Jan 15;14(1):e21272. Kerr, Cadegiani, Baldi, Lobo, … Chamie-Quintero. The discussion of this paper begins at about Minute 8 in the video below. The entire population of a city in Brazil was invited to take Ivermectin at a dose … Continue reading
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Informatics in Medicine Unlocked, 29 (2022) 100894. Hasan, Khan, Chowdhury, Khan, Moni, & Rahman This study, done in Bangladesh and Australia, compared something called “docking” ability of Quercetin with that of the usual drugs for several diseases, and found that … Continue reading
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EBioMedicine, 17 (2017), 192-198 (Authors: Mogensen, Andersen, Rodrigues, Benn, Aaby) The authors examined the outcome of the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s. They followed the children … Continue reading
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PLoS ONE, 10(4): e0126314. Food allergies in children have been increasing in recent decades, so there is a need to create an allergic animal model in order to study this problem. This is normally accomplished by giving the rats a … Continue reading
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MedRxiv, October 8, 2021. DOI: 10.1101/2021.08.19.21262139 The authors analyzed 1,373 persons with Covid-19 in the San Francisco Bay Area from February 1 to June 30, 2021. 125 of them had vaccine breakthrough infections. They found that symptomatic breakthrough infections had … Continue reading
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Immunobiology, 221 (2016), 512-515. Subclinical Bordetello pertussis colonizes the nasopharynx (nose) in vaccinated people, but has long been thought to be harmless. The authors show that on the contrary, this is an important cause of multiple sclerosis. Interestingly, the Bordatello … Continue reading
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European Journal of Pharmacology, Jan 15;891:173694 The authors recommend that instead of using Hydroxychloroquine (HCQ) together with the macrolide antibiotic Azithromycin, doctors should first use HCQ and follow this with the addition of Azithromycin. The picture at right describes the … Continue reading
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Journal of Antimicrobial Chemotherapy, 2021 Aug 12;76(9):2415-2418 Several drug treatment trials were reviewed in this paper, including the use of Hydroxychloroquine + Azithromycin, Hydroxychloroquine alone, IL-6 Inhibitors, Corticosteroids, Convalescent Plasma, Remdesivir, and “others” including five antiretroviral drugs and two anti-influenza … Continue reading
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Journal of Controlled Release, 329 (2021), 758-761. Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this paper, the authors discuss … Continue reading
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The Journal of Antibiotics, 73: 593-602. This is a comprehensive systematic review, summarizing the antiviral effects of ivermectin over the past 50 years. Ivermectin plays a role in several biological mechanisms; therefore it could serve as a potential candidate in … Continue reading
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Journal of Medical Virology, Oct;93(10):5833-5838 In an effort to see if Ivermectin would be effective in patients hospitalized with Covid-19, the authors gave half of them 12 mg of the drug for 3 (three) days. There were 82 patients in … Continue reading
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Frontiers in Public Health, Mar 19;6:79 Dr. Aaby was involved in the original introduction of the DPT vaccine to children in this African country in 1981. Even now, it is the most commonly used vaccine in low-income countries with poor … Continue reading
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International Journal of Molecular Sciences. 21(22):8803. This is a complex study of Remdesivir’s activity against the cytokine storm sometimes seen in cases of Covid-19. MP1032 (Remdesivir) is a reactive-oxygen scavenger (ROS) and was originally being developed to treat psoriasis, rheumatoid … Continue reading
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American Journal of Therapeutics 28, e2999-e318 This is a meta-analysis of 18 randomized controlled treatment trials of ivermectin for COVID-19. CONCLUSIONS: The meta-analysis found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, … Continue reading
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Lately, I have been asked to “prove” that the VAERS system for tracking vaccine injuries reports only a small percentage (less than 1%) of those injuries. I have also been asked to discuss whether such injuries are verified, and how. … Continue reading
