Category Archives: 2016-2020

Rubin 2016: The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis

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Immunobiology, 221 (2016), 512-515. Subclinical Bordetello pertussis colonizes the nasopharynx (nose) in vaccinated people, but has long been thought to be harmless.  The authors show that on the contrary, this is an important cause of multiple sclerosis. Interestingly, the Bordatello … Continue reading

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Khan 2020: Ivermectin treatment may improve the prognosis of patients with COVID-19

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Archivos de Bronconeumologia, 2020;56(12):816–830 The authors describe a clinical study in Bangladesh, in which half of 248 patients (without underlying conditions) received standard care, while half received standard care plus ivermectin.   A 12 mg dose of ivermectin was given just … Continue reading

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Portmann-Baracco 2020: Antiviral and anti-inflammatory properties of ivermectin and its potential use in COVID-19

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Archivos de Bronconeumologia, 56(12): 831-836. This is a letter to the editor describing the experimental use of Ivermectin for Covid-19. Ivermectin is a safe and well tolerated drug often used as a single dose for parasitosis. Thus, they used a … Continue reading

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Heidary 2020: Ivermectin–A systematic review from antiviral effects to COVID-19 complementary regimen

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The Journal of Antibiotics, 73: 593-602. This is a comprehensive systematic review, summarizing the antiviral effects of ivermectin over the past 50 years. Ivermectin plays a role in several biological mechanisms; therefore it could serve as a potential candidate in … Continue reading

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Elgazzar 2020: Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic

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Preprint:  Research Square. Ivermectin was approved for animal use in 1981, and a few years later it was approved for humans for treatment of roundworm and parasites.  Drs. William Campbell and Satoshi Omura received the 2015 Nobel Prize in Physiology … Continue reading

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Aaby 2018: Evidence of increase in mortality after the introduction of Diphtheria-Tetanus-Pertussis vaccine to children aged 6-35 months in Guinea-Bissau: A time for reflection?

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Frontiers in Public Health, Mar 19;6:79 Dr. Aaby was involved in the original introduction of the DPT vaccine to children in this African country in 1981.   Even now, it is the most commonly used vaccine in low-income countries with poor … Continue reading

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Schumann 2020: Immune-modulating drug MP1032 (Remdecivir) with SARS-CoV-2 antiviral activity in vitro: A potential multi-target approach for prevention and early intervention treatment of COVID-19

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International Journal of Molecular Sciences. 21(22):8803. This is a complex study of Remdecivir’s activity against the cytokine storm sometimes seen in cases of Covid-19. MP1032 (Remdecivir) is a reactive-oxygen scavenger (ROS) and was originally being developed to treat psoriasis, rheumatoid … Continue reading

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Caruso 2020: Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic

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Medical Hypotheses.  144(2020) 109910. Caruso et al reviewed 26 published studies on the use of Hydrogen Peroxide (H2O2) against viruses, considering its possible use when transmission has first happened, and the H2O2 may be able to enhance the innate immune … Continue reading

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Brownstein 2020: A novel approach to treating COVID-19 using nutritional and oxidative therapies

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Science, Public Health Policy, and the Law, Volume 2: 4-22. July 2020 Of 107 patients diagnosed with COVID-19 were given individualized treatments of Vitamin A,  Vitamin C, Vitamin D, Iodine, Nebulized and/or IV Hydrogen Peroxide, intramuscular therapies, IV Vitamin C, … Continue reading

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Wopara 2020: Synthetic food dyes cause testicular damage via up-regulation of pro-inflammatory cytokines and down-regulation of FSH-R and TESTK-1 gene expression

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JBRA Assisted Reproduction.  Online ahead of print Every now and again the rumor surfaces that soda can cause infertility or a lower sperm count.  According to Live Science, this is an urban myth. In fact, they say Mountain Dew (a … Continue reading

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Covid-19 vaccine & Microvascular Injury

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Back in December, 2020, before the vaccine rollout was well underway, Dr. J. Patrick Whelan of UCLA sent a warning to the FDA (see it below).  They duly posted it at their website, but otherwise appear to have ignored it. … Continue reading

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Derwand 2020: COVID-19 outpatients: Early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: A retrospective case series study

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International Journal of Antimicrobial Agents. Dec;56(6):106214. Most studies of Covid-19 involve very sick hospitalized patients. The authors are testing the use of Hydroxycholoroquine (HCQ) plus zinc and an antibiotic (for prevention of secondary lung infection) as an early treatment beginning … Continue reading

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Abd-Elsalam 2020: Hydroxychloroquine in the treatment of COVID-19: a multicenter randomized controlled study

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American Journal of Tropical Medicine & Hygiene. 103(4), pp. 1635-1639 From the chart, you might think that the authors would  have concluded that HCQ (Hydroxychloroquine) is a useful treatment for Covid-19, but according to their statistical analysis, they actually concluded … Continue reading

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What About Colostrum?

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All mammals nurse their young, feeding them milk produced in their mammary glands. Before the “true” milk itself is produced, however, another fluid called colostrum is provided. It is rich in nutrients as well as various growth factors; it is … Continue reading

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Lykkesfeldt 2019: The Pharmacokinetics of Vitamin C

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Nutrients. 11, 2412. Review. Although humans have the gene to make Vitamin C (as most other animals do), that gene is inactive.  Thus, humans must get it solely from dietary sources.   Because of the way it is taken up and … Continue reading

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Bosch 2020: A two arm randomized controlled trial comparing the short and long term effects of an elimination diet and a healthy diet in children with ADHD (TRACE study). Rationale, study design and methods.

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Study Protocol. BioMed Central Ltd. Psychiatry. 20: 262 This study has not yet happened.  It is intended to compare two dietary treatments (an elimination diet and a “healthy” diet) and  “Care As Usual” (medication).  It is being done in the … Continue reading

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Llewellyn 2020: Food color additives in the US food supply: Review of neurobehavioral safety

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Journal of Pediatric Neurology & Neuroscience. 4(1), 55-72. Case Report. This study was funded by the International Association of Color Manufacturers (IACM)  in response to the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA), which became concerned … Continue reading

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Al-Zalabani 2019: Association between soft drinks consumption and asthma: A systematic review and meta-analysis

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British Medical Journal Open. 9:e029046. Reviewing numerous studies involving children, adults, and prenatal exposure, the authors concluded that consumption of soft drinks is associated with significantly increased odds of asthma in both adults and children, as well as marginally significant … Continue reading

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Schultz 2016: Acetaminophen use for fever in children associated with autism spectrum disorder

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Autism Open Access. April; 6(2) Because this is a study on older children, fewer of the children with autism use acetaminophen (Tylenol) as the first choice for fever reduction.  Furthermore, acetaminophen is not effective at reducing fever for significantly more … Continue reading

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Catteau 2020: Low-dose hydroxychloroquine therapy and mortality in hospitalised patients with COVID-19: A nationwide observational study of 8075 participants. 

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International Journal of Antimicrobial Agents. Oct;56(4):106144. In Belgium, HCQ has been used off-label for hospitalized patients with Covid-19.  The authors compared patients receiving HCQ for 5 days to patients receiving only supportive care. As can be seen in Fig. 1, … Continue reading

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Meo 2020: Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

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European Review for Medical & Pharmacoloical Sciences. 24: 4539-4547. Using information from the WHO, ISI-Web of Knowledge, Thomson Reuter journals, PubMed, Medline, and clinical trial registries, the authors concluded their findings support the hypothesis that HCQ has efficacy in treatment … Continue reading

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Mahevas 2020: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: Observational comparative study using routine care data

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British Medical Journal.  369: m1844. All the patients in this study were in various hospitals. They all needed oxygen and had developed pneumonia.  An unknown number of the group given HCQ were not treated for the first two days after … Continue reading

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Giammaria 2020: Can early treatment of patients with risk factors contribute to managing the COVID-19 pandemic?

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Journal of Global Health, 10(1). June 2020 Basically, their answer is YES. Only about 20% of patients with COVID-19 develop serious symptoms, which seem to take about a week to come on, giving time to identify those at risk and … Continue reading

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Gbinigie 2020: Should chloroquine & hydroxychloroquine be used to treat COVID-19? A rapid review

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British Journal of General Practice, 2020 Jun; 4(2) This is another review of studies published by March 2020, and only 3 studies were discussed. They are listed in Table 1 in the document. Of these three studies, the one from … Continue reading

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Marmor 2020: COVID-19 and Chloroquine/Hydroxychloroquine: Is there ophthalmological concern?

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American Journal of Ophthalmology (editorial), 2020 May; 213: A3–A4. and Aug; 216: A1–A2. This is an editorial about the concern that while the antivirals HCQ and CQ may be helpful for COVID-19, they can cause retinal damage at high dosage … Continue reading

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Garcia-Cremades 2020: Full text Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing

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Clinical Pharmacology & Therapeutics. 2020 Aug;108(2):253-263 Using pharmacokinetics integrated with in vitro data, the authors are attempting to define the best dose for HCQ both for treatment and for clinical trials, while avoiding the heart QT problem of higher doses. … Continue reading

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Singh 2020: Chloroquine & hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search & a narrative review with a special reference to India & other developing countries.

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Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14(4), 241-146. The authors reviewed two studies on humans. concluding that due to the “minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India … Continue reading

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Shah 2020: A systematic review of the prophylactic role of chloroquine & hydroxychloroquine in coronavirus disease-19 (COVID-19)

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International Journal of Rheumatic Diseases, 2020 May;23(5):613-61. This is a review of all the (few) studies on the use of HCQ and the similar CQ for COVID-19 published by March, 2020. They searched a number of databases but only found … Continue reading

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Rajcumar 2020: Knowledge & misconceptions of parents of children with attention-deficit hyperactivity disorder at a hospital in South Africa

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South African Family Practice,2020 Sep. 3; 62(1): e1-e8 This paper is about a survey of 79 parents of ADHD children aged 5 to 17, in South Africa.  The authors report that 92.4% of the parents believed that “reducing sugar or … Continue reading

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Lee 2020: Dietary patterns are associated with attention-deficit hyperactivity disorder (ADHD) symptoms among preschoolers in South Korea: A prospective cohort study

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Nutritional Neuroscience, 2020 Sep 4:1-9 In a large group of children followed from birth, data on diet and behavior were obtained on 535 children at both 4 and 6 years old. The foodsinvestigated were divided into four basic groups: Sweet:  … Continue reading

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Yan 2018: Dietary patterns are associated with attention-deficit/hyperactivity disorder (ADHD) symptoms among preschoolers in mainland China

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European Journal of Clinical Nutrition, November 2018; 72 (11):1517-1523. The authors studied several eating patterns among Chinese children.  While the “processed,” “snack,” and “beverage” dietary patterns were all positively associated with ADHD symptoms, the “vegetarian” (more natural) dietary pattern was … Continue reading

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Farsad-Naeimi 2020: Sugar consumption, sugar sweetened beverages and Attention Deficit Hyperactivity Disorder: A systematic review and meta-analysis

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Complementary Therapies in Medicine, 53 (2020) This paper is a meta-analysis of seven studies considering sugar consumption and ADHD.  The authors concluded there is a “positive relationship between overall sugar and sugar-sweetened beverages consumption and symptoms of ADHD.” The authors … Continue reading

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Bakthavachalu 2020: Food Color and Autism: A meta-analysis

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Advances in Neurobiology (2020) 24:481-504 While the research does not prove causation, there seems to clearly be a link between food dyes and symptoms of autism.  Not only are there direct neurotoxic effects, but it has been shown that at … Continue reading

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Dolp 2020: Oligoantigenic diet improved children’s ADHD rating scale scores reliably in added video-rating

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Frontiers in Psychiatry, August 2020, Volume 11, 730, pp. 1-12 An oligoantigenic diet is a few-foods diet, used sometimes to identify foods a child may be allergic to.  It excludes all the food dyes, preservatives, and other additives, as well … Continue reading

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Kirkland 2020: Artificial food coloring affects EEG power and ADHD symptoms in college students with ADHD: A pilot study.

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Kirkland AE, Langan MT, & Holton KF, Nutritional Neuroscience (2020), DOI: 10.1080/1028415X.2020.1730614 Although this is a small pilot study, and the first to consider young adults, it indicates that food dyes may affect both brainwave activity and ADHD symptoms in … Continue reading

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Fake Information Describes Feingold Diet

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Healthline Media claims to be “creating a stronger healthier world” by providing “clear, credible, evidence-based health and wellness information that’s distinguished by its compassion for the human experience.” One of its most recent articles, dated September 29, 2020, is failing … Continue reading

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Pure Facts Excerpts and Archive

Newsletter of the Feingold Association of the United States Read more … Want more? See the ARCHIVES beginning 1981 How can parents help their ADHD child? In the controversy over whether or not to use medication, some important issues are … Continue reading

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HCQ — the Good, the Bad, & the Ugly

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There has been a lot of controversy about the use of Hydroxychloroquine (HCQ) as a treatment of COVID-19. This is an old antiviral medication, in use for more than 60 years, and considered safe for daily use even during pregnancy, … Continue reading

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Let’s get educated on vaccines

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(Updated July 17, 2020)If you have concerns about what is going on in the world of vaccines, you are not alone. I have long been collecting the research on all sides of this issue, and have begun organizing the studies … Continue reading

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How genetics and environment work together to shape our destiny: Milena Georgieva at TEDxAUBG

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Milena Georgieva is a young scientist in Bulgaria with lots of prestigious awards for best scientific excellence practices. Here, she describes the way our DNA functions. The way we live, the way we talk, the way we breathe and the … Continue reading

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A new collection of studies on the relationship of food dyes to health

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Just finished: a compilation of all the studies I can find on the food dyes used in the US and their connection with behavior and health. Download here(190 pages) This project was created to help the California Office of Environmental … Continue reading

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El-Desoky 2017: Curcumin Protects Against Tartrazine-Mediated Oxidative Stress and Hepatotoxicity in Male Rats

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European Review for Medical & Pharmacological Sciences. (21): 635-645. Curcumin (an extract of turmeric) was studied to see if it could protect against the kidney and liver damage expected from the ADI of Tartrazine (Yellow 5) given in the diet. … Continue reading

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Al-Seeni 2018: Nigella Sativa Oil Protects Against Tartrazine Toxicity in Male Rats.

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Toxicology Reports. 5: 146-155. This was not a test of tartrazine (Yellow 5) – they already knew it would be toxic.  Rats in the “positive control” group (given Yellow 5) had elevated liver enzymes, cholesterol and triglycerides, as well as … Continue reading

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Don’t miss this free seminar series

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If you, or your child, have a tic disorder or Tourette’s Syndrome, you may feel like the disorder controls your life.   But there is hope — you can manage a tic disorder, naturally, so that you feel in control. Don’t … Continue reading

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Rodrigo 2018: Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study

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Nutrients.  May 7;10(5). pii: E573. Rodrigo says that Tourette Syndrome (GTS) and gluten sensitivity may be associated.  23 children and 6 adults were put on a gluten-free diet and followed for a year.    They found a “marked reduction” in tics, … Continue reading

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Ludlow 2018: Understanding the Impact of Diet and Nutrition on Symptoms of Tourette Syndrome: A Scoping Review

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Journal of Child Healthcare. Mar;22(1):68-83 Ludlow and Rogers want to write a review of existing studies, but actually they are stuck with anecdotal reports because so little research has been done in this area.  As they say, however, “anecdotal reports … Continue reading

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Briguglio 2018: Dietary Neurotransmitters: A Narrative Review on Current Knowledge

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Nutrients. May 10;10(5). pii: E591 Some of the many substances found in foods are neurotransmitters (NT), including acetylcholine, glutamate, GABA, dopamine, serotonin and histamine.   Not only are these neurotransmitters part of the food itself, but they may be added or … Continue reading

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Dufault 2018: Food labeling requirements may explain lower autism and ADHD prevalence in the United Kingdom

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Integrative Food, Nutrition and Metabolism, 2018, 5(4): 1-2 This editorial explores possible nutritional reasons for the huge difference between the United States and the United Kingdom in numbers of children diagnosed with ADHD or autism. After two separate studies in … Continue reading

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Li 2018: Inedible Azo Dyes and Their Analytical Methods in Foodstuffs and Beverages

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Journal of AOAC International, Vol. 101.  (epublished ahead of print) This guest editorial is not about the food dyes we know and don’t love — it’s about inedible, dangerous food dyes that are used illegally in foods.  There is a … Continue reading

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Prabhakaran 2017: Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.

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Pharmacotherapy. 2017 May;37 (5): 607-610. Albuterol in bottles used for multiple dosing contains benzalkonium chloride (BAC) as a preservative.  The authors say that many pediatric hospitals use this kind of albuterol when preparing solutions for continuous nebulized albuterol for asthma … Continue reading

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Tseng 2018: Peripheral iron levels in children with attention-deficit hyperactivity disorder: A systematic review and meta-analysis

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Scientific Reports,  2018 Jan 15;8(1):788. 17 studies on iron and ADHD were analyzed by Tseng et al in Taiwan. Iron does more than prevent anemia; besides helping in  homeostatis of the hemoglobin (red blood cell) structure, iron is important to the … Continue reading

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Leo 2018: Occurrence of Azo Food Dyes and their Effects on Cellular Inflammatory Responses

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Nutrition. 2018 February. 46:36-40 This study found that 11.54% of the 1,681 processed items examined in a local supermarket in Singapore contained at least one of five food dyes — of which tartrazine (Yellow 5), sunset yellow (Yellow 6), and … Continue reading

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Rainbow-colored cake anybody?

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In study after study, the dangers of artificial food dyes are documented.  Nevertheless, many of us would still like to provide colorful party foods for our families.  What to do?  Of course, bright fruits such as blueberries and strawberries can … Continue reading

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Choudhary 2017: Neurophysiological symptoms and aspartame: What is the connection?

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Nutritional Neuroscience, 2017 Feb 15:1-11. This is a review of studies linking neuro-physiological symptoms to aspartame usage which concludes that aspartame may be responsible for adverse neurobehavioral health outcomes. QUOTE:  “Aspartame consumption needs to be approached with caution due to … Continue reading

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Soffer 2016: A case of chronic contact dermatitis resulting from the use of blue hair dye

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Contact Dermatitis. 2016 Oct;75(4): 258-9 This is a case report about a 45-year-old woman who began to dye her hair blue.  After several years of rashes and itching on her scalp, face, and neck, she sought help from an allergist.  … Continue reading

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Mawson 2017: Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children

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Journal of Translational Science, Volume 3(3): 1-12.  doi: 10.15761/JTS.1000186 This is one of the first studies done to address the questions raised by the U.S. Institute of Medicine about the long term health outcomes of the vaccination schedule as used … Continue reading

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Senate Health Committee approves Wieckowski bill to study dangers of synthetic food dyes on children

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SB 504 calls for state office to conduct independent review of evidence and options for the Legislature April 26, 2017 The Senate Health Committee today approved a bill by Senator Bob Wieckowski (D-Fremont) to direct a state agency to review … Continue reading

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Khayyat 2017: Tartrazine induces structural and functional aberrations and genotoxic effects in vivo

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PeerJ. 2017 Feb 23;5: e3041. This study was done to evaluate the possible adverse effects of the color Tartrazine (Yellow 5) on kidney and liver function and structure in rats, as well as its affect on white blood cells.  For … Continue reading

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Feitosa 2017: Estimate of the theoretical maximum daily intake of Sunset Yellow FCF by the Brazilian population

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Food Additives & Contaminants Part A. 2017 Feb 20:1-8 This study was  able to estimate daily intake of foods containing Sunset Yellow (Yellow 6) using the 2008-2009 data collections of food purchases by the Brazilian Institute of Geography and Statistics.  … Continue reading

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Bastaki 2017: Estimated Daily Intake and Safety of FD&C Food Colour Additives in the US Population

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Food Additives & Contaminants, Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 2017 March 23. Using complex statistics and a database of product  labels, rather than direct measurements, an  “estimate of daily intake” of the amounts of synthetic food … Continue reading

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