Category Archives: Brain

Jones 2023: Learning and memory deficits produced by aspartame are heritable via the paternal lineage

This gallery contains 1 photo.

Scientific Reports, Aug 31;13(1):14326. Jones, McCarthy, Stanwood, Schatschneider, Bhide Mice who drank the equivalent of only 16 oz to 32 oz of diet soda per day seemed just fine — but their babies weren’t.  Both male and female pups had … Continue reading →

More Galleries | Leave a comment

Jo 2011: Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G.

This gallery contains 2 photos.

Jo, Bean.  Molecular Pharmacology. 80:  247-257. BBG, a variant of Brilliant Blue (Blue 1) is a P2X7 receptor antagonist and is shown to also block neuronal sodium channels. It is the most potent agent yet found that interacts with sodium … Continue reading →

More Galleries | Leave a comment

Irwin 2013: Different Fates of Alzheimer’s Disease Amyloid-beta Fibrils Remodeled by Biocompatible Small Molecules

This gallery contains 2 photos.

Irwin, Wong, Kwon. Biomacromolecules. 14(1): 264- 274. Amyloid fibrils such as those found in Alzheimer’s disease are thermodynamically very stable, but there is evidence that small molecules like food dyes can remodel them safely. The authors performed a remodeling trial … Continue reading →

More Galleries | Leave a comment

Ferrazoli 2017: Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson’s Disease

This gallery contains 2 photos.

Cell Transplantation. 26: 669-677.   Ferrazoli, de Souza, Nascimento . . . & Ulrich This paper describes an effect of Blue 1 of  potential medical benefit in Parkinson’s disease.   Basically, it can be used to suppress a receptor that is over-active … Continue reading →

More Galleries | Leave a comment

Ganeshpurkar 2017: The Pharmacological Potential of Rutin

This gallery contains 4 photos.

Saudi Pharmaceutical Journal. 25, 149-164.  Ganeshpurkar & Saluja.  This is a comprehensive review of Rutin — a natural-source pharmaceutical that has an almost unbelievable profile of benefits.  It is found in many sources, including passion flowers, apples, and buckwheat (kasha). … Continue reading →

More Galleries | Leave a comment

Dalal 2010: Involvement of High Plasma Corticosterone Status and Activation of Brain Regional Serotonin Metabolism in Long-Term Erythrosine-Induced Rearing Motor Hyper Activity in Young Adult Male Rats.

This gallery contains 2 photos.

Toxicology Mechanisms & Methods. 20(6):287- 297.  Dalal & Poddar. This study investigated a long-term trial of Erythrosine (Red 3) in rats. 10 – 100 mg/kg/day of Red 3 increased plasma corticosterone levels after several days of administration, similar to pargyline, … Continue reading →

More Galleries | Leave a comment

Dalal 2009: Short-Term Erythrosine B-Induced Inhibition of the Brain Regional Serotonergic Activity Suppresses Motor Activity (Exploratory Behavior) of Young Adult Mammals.

This gallery contains 3 photos.

Pharmacology, Biochemistry, and Behavior. 92(2009): 574-582.   Dalal &Poddar. Long-term administration of Erythrosine B (Red 3) increased movement in a dose-dependent manner, but Dalal wanted to test a single large dose in vivo. Dalal said Red 3 is known to increase … Continue reading →

More Galleries | Leave a comment

Amchova 2015: Health Safety Issues of Synthetic Food Colorants

This gallery contains 1 photo.

Regulatory Toxicology and Pharmacology. 73(3): 914-922. This is a review of food dye toxicity per official EFSA reports and other studies since 2008. Prenatal exposure to mixtures of food dyes can damage spatial working memory, and may affect brain signaling.  … Continue reading →

More Galleries | Leave a comment

Edelkind-Noesges 2020: Vaccine Adjuvants and Selected Neurotoxins in ADHD and Autism

This gallery contains 1 photo.

Capstone for Masters Degree, Walden University, October 2020 This paper explores the connections between autism, everyday toxic exposures such as fluoridated water, and vaccine damage.  One important question, in particular, is whether the link may involve a deficiency of the … Continue reading →

More Galleries | Leave a comment

Patel 2022: The safety of pediatric use of paracetamol (acetaminophen): A narrative review of direct and indirect evidence

This gallery contains 2 photos.

Minerva Pediatrics, 2022. July 13 DOI: 10.23736/S2724-52765.22.06932-4 Use of Tylenol (paracetamol or acetaminophen) during pregnancy and early childhood has been considered safe since the 1970s.  Parents are urged to use it routinely after vaccination to prevent or control fever. It … Continue reading →

More Galleries | Leave a comment

Umezawa 2012: Effect of fetal exposure to titanium dioxide nanoparticle on brain development – brain region information

This gallery contains 2 photos.

The Journal of Toxicological Sciences, Vol. 37, No. 6, 1247-1252. 2012 By studying the brains of mice whose mothers were exposed to titanium dioxide (TiO2) nanoparticles during pregnancy, the researchers determined changes in gene expression affecting several parts of the … Continue reading →

More Galleries | Leave a comment

Omura 2015: Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment

This gallery contains 2 photos.

Acupuncture & Electro-Therapeutics Research., Vol. 40,  pp. 157-187, 2015 Omura reports on a non-invasive method developed to detect neurotransmitters, bacteria, metals, virus, and other abnormal molecules using an electromagnetic field resonance phenomenon through the pupil of the eye. The researchers … Continue reading →

More Galleries | Leave a comment

Ze 2014: Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles

This gallery contains 3 photos.

Journal of Biomedical Materials Research Part A. 2014 Feb; 102(2): 470-8. Titanium dioxide is a naturally occurring white powder approved by the FDA.  It is used as a white coloring in many products we use every day such as toothpaste, … Continue reading →

More Galleries | Leave a comment

Edlow 2016: Maternal Obesity and Neurodevelopmental and Psychiatric Disorders in Offspring

This gallery contains 2 photos.

Prenatal Diagnosis. 2016, Sep 29. doi: 10.1002/pd.4932 Edlow reviews the current animal and human research showing a connection between maternal (and sometimes paternal) obesity and high fat diets on  neuro-developmental and psychiatric disorders in the offspring. These disorders include cognitive … Continue reading →

More Galleries | Leave a comment

Goldenring 1980: Effects of continuous gastric infusion of food dyes on developing rat pups.

This gallery contains 2 photos.

Life Sciences. 1980 Nov 7;27(20):1897-904.  Goldenring, Wool, Shaywitz, Batter, Cohen, Young, & Teicher In this study, some rats were treated with 6-OHDA and some were treated with placebo.  In each of these groups, some were given food dyes and some were given placebo, resulting in … Continue reading →

More Galleries | Leave a comment

Eagle 2014: ADHD impacted by sulfotransferase (SULT1A) inhibition from artificial food colors and plant-based foods

This gallery contains 2 photos.

Physiology & Behavior, 135 (2014), 174-179. SULT1A inhibitors in foods, including natural substances and artificial food colors, have a role in ADHD that can both worsen or improve symptoms. … SULT1A inhibition can influence brain catecholamines through the intermediary of … Continue reading →

More Galleries | Leave a comment

Liu 2005: Biosocial bases of aggressive and violent behavior — implications for nursing studies

This gallery contains 2 photos.

International Journal of Nursing Studies, 2005 Feb;42(2):229-41 In this review, it is noted that deficiencies in cholesterol, tryptophan (an amino acid), protein, iron, or zinc are each connected to an increase in aggression as well as cognitive and behavior problems.  … Continue reading →

More Galleries | Leave a comment

Horrocks 1999: Health benefits of docosahexaenoic acid (DHA)

This gallery contains 3 photos.

Pharmacological Research, 1999.  Sep;40 (3):211-25 DHA  and EPA are long-chain omega-3 fatty acids.  This review lists the many benefits of these as well as the effects of a deficiency in both infants and adults. QUOTE:  “… deficiencies of DHA are … Continue reading →

More Galleries | Leave a comment

Husarova 2013: Monosodium glutamate toxic effects and their implications for human intake: A review

This gallery contains 1 photo.

JMED Research, Vol. 2013 (2013) This is a review of the studies about MSG and its influence on different systems in humans.  Effects of injected MSG into rats included neuron damage, and prefrontal cerebral cortex changes, but such tests cannot … Continue reading →

More Galleries | Leave a comment

Lafferman 1979: Erythrosin B inhibits dopamine transport in rat caudate synaptosomes.

This gallery contains 2 photos.

Science. 1979. July 27; 205 (4404): 410-2. Lafferman found that erythrosin B [Red 3] given to rats prevents the uptake of dopamine (the “feel good” neurotransmitter) by nerve cells in the brain called the caudate synaptosomes.  This is consistent with … Continue reading →

More Galleries | Leave a comment