Category Archives: Brain

Jones 2023: Learning and memory deficits produced by aspartame are heritable via the paternal lineage

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Scientific Reports, Aug 31;13(1):14326. Jones, McCarthy, Stanwood, Schatschneider, Bhide Mice who drank the equivalent of only 16 oz to 32 oz of diet soda per day seemed just fine — but their babies weren’t.  Both male and female pups had … Continue reading

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Jo 2011: Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G.

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Jo, Bean.  Molecular Pharmacology. 80:  247-257. BBG, a variant of Brilliant Blue (Blue 1) is a P2X7 receptor antagonist and is shown to also block neuronal sodium channels. It is the most potent agent yet found that interacts with sodium … Continue reading

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Irwin 2013: Different Fates of Alzheimer’s Disease Amyloid-beta Fibrils Remodeled by Biocompatible Small Molecules

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Irwin, Wong, Kwon. Biomacromolecules. 14(1): 264- 274. Amyloid fibrils such as those found in Alzheimer’s disease are thermodynamically very stable, but there is evidence that small molecules like food dyes can remodel them safely. The authors performed a remodeling trial … Continue reading

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Ferrazoli 2017: Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson’s Disease

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Ferrazoli, de Souza, Nascimento, Oliveira-Giacomelli, Schwindt, Britto, Ulrich.  Cell Transplantation. 26: 669-677. This paper describes an effect of Blue 1 ofpotential medical benefit in Parkinson’sdisease.   Basically, it can be used to suppress a receptor that is over-active and causing damage … Continue reading

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Patel 2022: The safety of pediatric use of paracetamol (acetaminophen): A narrative review of direct and indirect evidence

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Minerva Pediatrics, 2022. July 13 DOI: 10.23736/S2724-52765.22.06932-4 Use of Tylenol (paracetamol or acetaminophen) during pregnancy and early childhood has been considered safe since the 1970s.  Parents are urged to use it routinely after vaccination to prevent or control fever. It … Continue reading

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Umezawa 2012: Effect of fetal exposure to titanium dioxide nanoparticle on brain development – brain region information

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The Journal of Toxicological Sciences, Vol. 37, No. 6, 1247-1252. 2012 By studying the brains of mice whose mothers were exposed to titanium dioxide (TiO2) nanoparticles during pregnancy, the researchers determined changes in gene expression affecting several parts of the … Continue reading

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Omura 2015: Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment

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Acupuncture & Electro-Therapeutics Research., Vol. 40,  pp. 157-187, 2015 Omura reports on a non-invasive method developed to detect neurotransmitters, bacteria, metals, virus, and other abnormal molecules using an electromagnetic field resonance phenomenon through the pupil of the eye. The researchers … Continue reading

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Ze 2014: Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles

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Journal of Biomedical Materials Research Part A. 2014 Feb; 102(2): 470-8. Titanium dioxide is a naturally occurring white powder approved by the FDA.  It is used as a white coloring in many products we use every day such as toothpaste, … Continue reading

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Liu 2005: Biosocial bases of aggressive and violent behavior — implications for nursing studies

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International Journal of Nursing Studies, 2005 Feb;42(2):229-41 In this review, it is noted that deficiencies in cholesterol, tryptophan (an amino acid), protein, iron, or zinc are each connected to an increase in aggression as well as cognitive and behavior problems.  … Continue reading

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Horrocks 1999: Health benefits of docosahexaenoic acid (DHA)

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Pharmacological Research, 1999.  Sep;40 (3):211-25 DHA  and EPA are long-chain omega-3 fatty acids.  This review lists the many benefits of these as well as the effects of a deficiency in both infants and adults. QUOTE:  “… deficiencies of DHA are … Continue reading

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Husarova 2013: Monosodium glutamate toxic effects and their implications for human intake: A review

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JMED Research, Vol. 2013 (2013) This is a review of the studies about MSG and its influence on different systems in humans.  Effects of injected MSG into rats included neuron damage, and prefrontal cerebral cortex changes, but such tests cannot … Continue reading

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Lafferman 1979: Erythrosin B inhibits dopamine transport in rat caudate synaptosomes.

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Science. 1979. July 27; 205 (4404): 410-2. Lafferman found that erythrosin B [Red 3] given to rats prevents the uptake of dopamine (the “feel good” neurotransmitter) by nerve cells in the brain called the caudate synaptosomes.  This is consistent with … Continue reading

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