Gao, Li, Shen, Yin, An, Jin. Journal of Food Science. 76(6): T125-T129.
Middle and high Tartrazine (Yellow 5) doses produced learning and memory deficits.
Doses are equivalent to 40 and 80 mg/kg for humans, which is far above the ADI.
NOTE: It may be a typo, but the ADI level that they list for Tartrazine is 75 mg/kg, while the dosages they gave the animals corresponds, they say, to 80 mg/kg and 40 mg/kg. But the Japanese ADI is 7.5 mg/kg – not 75 — so the question is: Did they just miss the decimal? Did they mean they gave the animals 8.0 mg/kg and 4.0 mg/kg? Or are they giving 10 times the ADI on purpose?