Irwin 2013: Different Fates of Alzheimer’s Disease Amyloid-beta Fibrils Remodeled by Biocompatible Small Molecules

Irwin, Wong, Kwon. Biomacromolecules. 14(1): 264- 274.

Amyloid fibrils such as those found in Alzheimer’s disease are thermodynamically very stable, but there is evidence that small molecules like food dyes can remodel them safely.

The authors performed a remodeling trial using methylene blue, brilliant blue G (Blue 1) and erythrosine B (Red 3).

  • Methylene blue perturbed the fibrillary structure leading to amorphous aggregates
  • Blue 1 fragmented the fibrils into shorter fibrils
  • Red 3 separated the fibrils into protofibrils successfully.

All three are “promising candidates to remove insoluble amyloid fibrils deposited in the human brain.”

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