Spector 1979: Aspirin and concomitant idiosyncrasies in adult asthmatic patients

42254808 - 123RFJournal of Allergy & Clinical Immunology, 1979 Dec;64(6 Pt 1):500-6

In this study, a positive response was defined as a 20% fall in forced expiratory volume in 1 second  (FEV1) for up to 4 hours.  The researchers tested several hundred people, and got positive responses, as follows:

  • 44 of 230 patients with ASA (aspirin)
  • 11 of 277 with tartrazine (Yellow 5)
  • 2 of 93 with sodium salicylate
  • 2 of 69 with acetaminophen (Tylenol).

Everybody who reacted to tartrazine, sodium salicylate, or acetaminophen had also reacted to aspirin.  96% of them had sinusitis and 71% had nasal polyps.

The researchers used up to 650 mg aspirin (beginning with a lower dose if sensitivity was suspected), 600 mg sodium salicylate, and 650 mg Tylenol.  For the dye, patients were given only 1, 5, 15, 25, and 50 mg of Yellow 5, in incremental doses.

NOTE:  At least some of the patients were not on medications at the time of the study. It is not actually clear, but mention was made of “those patients whose medications could not be withheld and those receiving troleandomycin.”

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