International Journal of Biological Macromolecules. 98: 277-286.
This study investigated the interaction of Yellow 5 with the muscle protein myoglobin.
The dye interacts with myoglobin protein to form amorphous aggregates at a pH of 2.0 but not at a pH of 7.4, at which point the myoglobin charge changes and they repel each other.
Supportive testing suggests that Yellow 5 can cause aggregation in any
protein that is cationic (positively charged).