Journal of American Science, 2011; 7 (6): 1211-1218.
This paper from Egypt describes a double-blind controlled study on rats to determine the behavioral effects of long-term exposure to various doses of tartrazine (E102, Yellow 5) provided in the drinking water of the rats. A variety of tests were used to indicate hyperactivity, anxiety, depression, and social interaction. Details are provided in the full text.
QUOTE: “This study provides sufficient scientific evidence that a causal link truly exists between tartrazine and inflection of hyperactivity, anxiety and depression-like behaviours in rats and points to the hazardous impact of tartrazine on public health. ”
In their last sentence, while suggesting further research on food dyes, “in order to recognize their unexpected toxic effects,” they also suggested “prohibited use of harmful colours to ensure public health.”