Vaccine, 2017 Oct 13;35(43):5897-5904
This is a study funded by Merck and published in two parts (the part about whether the vaccine can provoke an immune response – and it can – was published in 2019, and is linked below).
This study is supposed to test the safety and efficacy of a pentavalent (5-part) rotavirus vaccine when it is used together with the DTaP & polio vaccines either all at once (concomitant) or staggered (at different times). Everybody gets the DTaP & polio, but some get it with the “real” vaccine and others with the “placebo.” So far, this sounds pretty good.
The study included a total of 4040 babies, divided equally between the RV5 and the placebo. Almost 86% of them in both groups got all 3 vaccinations and were followhttps://pubmed.ncbi.nlm.nih.gov/28935470/ed up for 30 days. The authors concluded that the vaccine is efficacious — of the 2020 getting the real vaccine, only 34 got diarrhea, while 108 got diarrhea in the placebo group. (33/2020 = The authors concluded that the side effects of the RV5 vaccine were no worse for the “real” vaccine than for the “placebo” and that anyhow almost none of them
