Category Archives: Alzheimer’s

Irwin 2013: Different Fates of Alzheimer’s Disease Amyloid-beta Fibrils Remodeled by Biocompatible Small Molecules

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Irwin, Wong, Kwon. Biomacromolecules. 14(1): 264- 274. Amyloid fibrils such as those found in Alzheimer’s disease are thermodynamically very stable, but there is evidence that small molecules like food dyes can remodel them safely. The authors performed a remodeling trial … Continue reading

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Ferreira 2016: Brilliant Blue Dyes in Daily Food: How Could Purinergic System be Affected?

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Ferreira, Faria, da Silva Ferreira, Soares-Bezerra.  International Journal of Food Science. 2016:7548498 Ferreira reviewed what was known about the medical uses of Blue 1. The purinergic system is widespread throughout the brain, nervous system and every other system in the … Continue reading

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Ganeshpurkar 2017: The Pharmacological Potential of Rutin

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Ganeshpurkar, Saluja. Saudi Pharmaceutical Journal. 25, 149-164. This is a comprehensive review of Rutin — a natural-source pharmaceutical that has an almost unbelievable profile of benefits.  It is found in many sources, including passion flowers, apples, and buckwheat (kasha). Prevents … Continue reading

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Al-Shabib 2019: Allura Red Rapidly Induces Amyloid-Like Fibril Formation in Hen Egg White Lysozyme at Physiological pH

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International Journal of Biological Macromolecules. 127: 297-305 Red 40, with hen egg white lysozyme (HEWL), forms amyloid-like aggregates. (A lysozyme is an enzyme in human tears and egg white.) The amyloid fibril formation can be observed by an electron microscope, … Continue reading

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Al-Shabib 2017: Unveiling the Stimulatory Effects of Tartrazine on Human and Bovine Serum Albumin Fibrillogenesis: Spectroscopic and Microscopic Study

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Spectrochimica Acta Part A:  molecular and Biomolecular Spectroscopy.  15(181(: 116-124. Tartrazine (Yellow 5) interacts with both human and bovine albumin to form amyloid fibrils such as those found in some neurodegenerative diseases such as Alzheimer’s. MedLine || Full Text

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Alzheimer’s, ALS, and Parkinson’s

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by Jane Hersey, 2022 Alzheimer’s disease was first recognized in 1906, and for decades the pharmaceutical industry has been searching for a drug that would prevent and/or treat it.  But after decades of effort and billions of dollars, there have … Continue reading

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Hasan 2022: In silico molecular docking and ADME/T analysis of Quercetin compound with its evaluation of broad-spectrum therapeutic potential against particular diseases

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Informatics in Medicine Unlocked, 29 (2022) 100894.  Hasan, Khan, Chowdhury, Khan, Moni, & Rahman This study, done in Bangladesh and Australia, compared something called “docking” ability of Quercetin with that of the usual drugs for several diseases, and found that … Continue reading

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Wopara 2021: Anxiogenic and memory impairment effect of food color exposure: Upregulation of oxido-neuroinflammatory markers and acetyl-cholinesterase activity in the prefrontal cortex and hippocampus

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Heliyon 7 (2021) e06378 Various doses of Erythrosine (Red 3) and Tartrazine (Yellow 5) were given to rats for six weeks. At that time, their behavior and ability to recognize objects was evaluated. At the end, their brains were studied … Continue reading

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A new collection of studies on the relationship of food dyes to health

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Just finished: a compilation of all the studies I can find on the food dyes used in the US and their connection with behavior and health. Download here(190 pages) This project was created to help the California Office of Environmental … Continue reading

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