El-Desoky 2017: Curcumin Protects Against Tartrazine-Mediated Oxidative Stress and Hepatotoxicity in Male Rats

curcuminEuropean Review for Medical & Pharmacological Sciences. (21): 635-645.

Curcumin (an extract of turmeric) was studied to see if it could protect against the kidney and liver damage expected from the ADI of Tartrazine (Yellow 5) given in the diet.

The Yellow 5 caused significant oxidative stress and decreased antioxidant enzymes, while elevating markers for kidney/liver damage, and causing liver changes including hemorrhage and vacuolization (actual holes).

Giving 2 or 4 g/kg curcumin with the dye almost completely prevented or reversed these effects, but giving only 1 g/kg didn’t help.

The author recommends using curcumin to “moderate potential effects of these artificial dyes” but stresses that decreasing or removing the dyes “is an essential step for the amelioration of human health status and decreasing risk of onset or progression of degenerative diseases.”

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