Khayyat 2017: Tartrazine induces structural and functional aberrations and genotoxic effects in vivo

Khayyat2017PeerJ. 2017 Feb 23;5: e3041.

This study was done to evaluate the possible adverse effects of the color Tartrazine (Yellow 5) on kidney and liver function and structure in rats, as well as its affect on white blood cells.  For 30 days, in addition to their normal food, rats in the control group were given 1 ml/kg body weight of distilled water, while rats in the Tartrazine group were given Tartrazine dissolved in 1 ml/kg distilled water at the human ADI (acceptable daily intake) level of 7.5 mg/kg of body weight.

The results were so dramatic that I am pasting the entire chart below:


Besides indicators of kidney and liver damage, the treated rats also had an increase of oxidative stress, as well as deformation of mitochondria.

QUOTE:  “According to the above-discussed results, it can be concluded that tartrazine is able to generate ROS (reactive oxygen species) thus accelerating oxidative stress, altering the structure and biochemical profiles in hepatic and renal tissues.  Therefore, controlling the consumption of tartrazine is important for the health and limiting the use of tartrazine, especially in foods used by children, is highly advisable.”

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