Masone & Chanforan, Computational Biology and Chemistry. 56(2015): 152-158.
Five artificial food dyes were compared to their “natural equivalents” in ability to bind to human serum albumin (HSA).
Note: In the case of binding to HSA, less is better.
The graph at left is extracted from Figure 4, comparing Yellow 5 to the natural dye curcumin (turmeric).
The dye binds stronger to HSA than the curcumin, as you can see in the picture. This supports the hypothesis that the artificial food dye is of potential risk to human health.