Blog Archives

Lykkesfeldt 2019: The Pharmacokinetics of Vitamin C

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Nutrients. 11, 2412. Review. Although humans have the gene to make Vitamin C (as most other animals do), it is inactive.  Thus, humans must get it solely from dietary sources.   Because of the way it is taken up and handled … Continue reading

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Bosch 2020: A two arm randomized controlled trial comparing the short and long term effects of an elimination diet and a healthy diet in children with ADHD (TRACE study). Rationale, study design and methods.

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Study Protocol. BioMed Central Ltd. Psychiatry. 20: 262 This study has not yet happened.  It is intended to compare two dietary treatments (an elimination diet and a “healthy” diet) and  “Care As Usual” (medication).  It is being done in the … Continue reading

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Llewellyn 2020: Food color additives in the US food supply: Review of neurobehavioral safety

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Journal of Pediatric Neurology & Neuroscience. 4(1), 55-72. Case Report. This study was funded by the International Association of Color Manufacturers (IACM)  in response to the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA), which became concerned … Continue reading

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Al-Zalabani 2019: Association between soft drinks consumption and asthma: A systematic review and meta-analysis

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British Medical Journal Open. 9:e029046. Reviewing numerous studies involving children, adults, and prenatal exposure, the authors concluded that consumption of soft drinks is associated with significantly increased odds of asthma in both adults and children, as well as marginally significant … Continue reading

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Schultz 2016: Acetaminophen use for fever in children associated with autism spectrum disorder

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Autism Open Access. April; 6(2) Because this is a study on older children, fewer of the children with autism use acetaminophen (Tylenol) as the first choice for fever reduction.  Furthermore, acetaminophen is not effective at reducing fever for significantly more … Continue reading

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Pottegard 2014: Children’s relative age in class and use of medication for ADHD: A Danish nationwide study

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Journal of Child Psychology & Psychiatry, 55(11). 1244-1250. In this study in Denmark, similar to the Zoega et al (2012) study in Iceland, the authors wanted to see if the younger children were more at risk of being prescribed ADHD … Continue reading

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Zoega 2012: Age, academic performance, and stimulant prescribing for ADHD: A nationwide cohort study

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Pediatrics, 130(6); 1012-1018 In a nationwide population-based study, the authors observed the effect of relative age on whether the child was likely to perform adequately in class and on whether the child would be prescribed medication for ADHD.  They found … Continue reading

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Zou 2011: Tourette syndrome and excitatory substances: Is there a connection?

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Child’s Nervous System, 27: 793-802. Using the same testing the International Olympic Committee uses for detecting prohibited excitatory substances, the authors attempted to find out if eating certain foods may create an excess of excitatory substances in the urine of … Continue reading

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Suglia 2013: Soft drinks consumption is associated with behavior problems in 5-year-olds

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The Journal of Pediatrics. 163(5); 1323-1328. The authors here attempted to determine the effect, if any, of soda consumption on aggressive behavior, attention problems, and withdrawn behavior among 5-year-olds.  Similar studies on older children had determined that consuming soft drinks … Continue reading

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Oplatowska-Stachowiak 2015: Food Colours: Existing and emerging food safety concerns

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Critical Reviews in Food Science and Nutrition. Feb 11;57(3):524-548. In addition to the problem of illegal and carcinogenic food dyes being added to foods — and the ongoing need to detect them — there is growing concern about the safety … Continue reading

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Catteau 2020: Low-dose hydroxychloroquine therapy and mortality in hospitalised patients with COVID-19: A nationwide observational study of 8075 participants. 

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International Journal of Antimicrobial Agents. Oct;56(4):106144. In Belgium, HCQ has been used off-label for hospitalized patients with Covid-19.  The authors compared patients receiving HCQ for 5 days to patients receiving only supportive care. As can be seen in Fig. 1, … Continue reading

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Meo 2020: Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

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European Review for Medical & Pharmacoloical Sciences. 24: 4539-4547. Using information from the WHO, ISI-Web of Knowledge, Thomson Reuter journals, PubMed, Medline, and clinical trial registries, the authors concluded their findings support the hypothesis that HCQ has efficacy in treatment … Continue reading

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Mahevas 2020: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: Observational comparative study using routine care data

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British Medical Journal.  369: m1844. All the patients in this study were in various hospitals. They all needed oxygen and had developed pneumonia.  An unknown number of the group given HCQ were not treated for the first two days after … Continue reading

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Giammaria 2020: Can early treatment of patients with risk factors contribute to managing the COVID-19 pandemic?

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Journal of Global Health, 10(1). June 2020 Basically, their answer is YES. Only about 20% of patients with COVID-19 develop serious symptoms, which seem to take about a week to come on, giving time to identify those at risk and … Continue reading

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Gbinigie 2020: Should chloroquine & hydroxychloroquine be used to treat COVID-19? A rapid review

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British Journal of General Practice, 2020 Jun; 4(2) This is another review of studies published by March 2020, and only 3 studies were discussed. They are listed in Table 1 in the document. Of these three studies, the one from … Continue reading

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Marmor 2020: COVID-19 and Chloroquine/Hydroxychloroquine: Is there ophthalmological concern?

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American Journal of Ophthalmology (editorial), 2020 May; 213: A3–A4. and Aug; 216: A1–A2. This is an editorial about the concern that while the antivirals HCQ and CQ may be helpful for COVID-19, they can cause retinal damage at high dosage … Continue reading

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Garcia-Cremades 2020: Full text Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing

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Clinical Pharmacology & Therapeutics. 2020 Aug;108(2):253-263 Using pharmacokinetics integrated with in vitro data, the authors are attempting to define the best dose for HCQ both for treatment and for clinical trials, while avoiding the heart QT problem of higher doses. … Continue reading

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Singh 2020: Chloroquine & hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search & a narrative review with a special reference to India & other developing countries.

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Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14(4), 241-146. The authors reviewed two studies on humans. concluding that due to the “minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India … Continue reading

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Shah 2020: A systematic review of the prophylactic role of chloroquine & hydroxychloroquine in coronavirus disease-19 (COVID-19)

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International Journal of Rheumatic Diseases, 2020 May;23(5):613-61. This is a review of all the (few) studies on the use of HCQ and the similar CQ for COVID-19 published by March, 2020. They searched a number of databases but only found … Continue reading

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Rajcumar 2020: Knowledge & misconceptions of parents of children with attention-deficit hyperactivity disorder at a hospital in South Africa

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South African Family Practice,2020 Sep. 3; 62(1): e1-e8 This paper is about a survey of 79 parents of ADHD children aged 5 to 17, in South Africa.  The authors report that 92.4% of the parents believed that “reducing sugar or … Continue reading

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Howard 2010: ADHD is associated with a “Western” dietary pattern in adolescents

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Journal of Attention Disorders, 2011 Jul;15(5):403-11. Complete data, including diet and ADHD diagnoses, were obtined on 1,172 adolescents (14 year olds) from the Raine Study which had been following children from birth. The authors noted that the “Western” dietary pattern … Continue reading

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Lee 2020: Dietary patterns are associated with attention-deficit hyperactivity disorder (ADHD) symptoms among preschoolers in South Korea: A prospective cohort study

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Nutritional Neuroscience, 2020 Sep 4:1-9 In a large group of children followed from birth, data on diet and behavior were obtained on 535 children at both 4 and 6 years old. The foodsinvestigated were divided into four basic groups: Sweet:  … Continue reading

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Yan 2018: Dietary patterns are associated with attention-deficit/hyperactivity disorder (ADHD) symptoms among preschoolers in mainland China

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European Journal of Clinical Nutrition, November 2018; 72 (11):1517-1523. The authors studied several eating patterns among Chinese children.  While the “processed,” “snack,” and “beverage” dietary patterns were all positively associated with ADHD symptoms, the “vegetarian” (more natural) dietary pattern was … Continue reading

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Farsad-Naeimi 2020: Sugar consumption, sugar sweetened beverages and Attention Deficit Hyperactivity Disorder: A systematic review and meta-analysis

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Complementary Therapies in Medicine, 53 (2020) This paper is a meta-analysis of seven studies considering sugar consumption and ADHD.  The authors concluded there is a “positive relationship between overall sugar and sugar-sweetened beverages consumption and symptoms of ADHD.” The authors … Continue reading

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Bakthavachalu 2020: Food Color and Autism: A meta-analysis

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Advances in Neurobiology (2020) 24:481-504 While the research does not prove causation, there seems to clearly be a link between food dyes and symptoms of autism.  Not only are there direct neurotoxic effects, but it has been shown that at … Continue reading

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Dolp 2020: Oligoantigenic diet improved children’s ADHD rating scale scores reliably in added video-rating

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Frontiers in Psychiatry, August 2020, Volume 11, 730, pp. 1-12 An oligoantigenic diet is a few-foods diet, used sometimes to identify foods a child may be allergic to.  It excludes all the food dyes, preservatives, and other additives, as well … Continue reading

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Kirkland 2020: Artificial food coloring affects EEG power and ADHD symptoms in college students with ADHD: A pilot study.

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Kirkland AE, Langan MT, & Holton KF, Nutritional Neuroscience (2020), DOI: 10.1080/1028415X.2020.1730614 Although this is a small pilot study, and the first to consider young adults, it indicates that food dyes may affect both brainwave activity and ADHD symptoms in … Continue reading

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Fake Information Describes Feingold Diet

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Healthline Media claims to be “creating a stronger healthier world” by providing “clear, credible, evidence-based health and wellness information that’s distinguished by its compassion for the human experience.” One of its most recent articles, dated September 29, 2020, is failing … Continue reading

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Pure Facts Excerpts and Archive

Newsletter of the Feingold Association of the United States Read more … Want more? See the ARCHIVES beginning 1981 How can parents help their ADHD child? In the controversy over whether or not to use medication, some important issues are … Continue reading

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HCQ — the Good, the Bad, & the Ugly

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There has been a lot of controversy about the use of Hydroxychloroquine (HCQ) as a treatment of COVID-19. This is an old antiviral medication, in use for more than 60 years, and considered safe for daily use even during pregnancy, … Continue reading

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Let’s get educated on vaccines

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(Updated July 17, 2020)If you have concerns about what is going on in the world of vaccines, you are not alone. I have long been collecting the research on all sides of this issue, and have begun organizing the studies … Continue reading

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How genetics and environment work together to shape our destiny: Milena Georgieva at TEDxAUBG

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Milena Georgieva is a young scientist in Bulgaria with lots of prestigious awards for best scientific excellence practices. Here, she describes the way our DNA functions. The way we live, the way we talk, the way we breathe and the … Continue reading

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Archives – FAWA 1979, March

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Letter from Dr. Feingold Greetings to all members of FAUS! It is almost six years since the AMA meeting in New York (June 1973), where I made the first public announcement linking food additives to behavioral disturbances and learning disabilities … Continue reading

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Archives – FAWA 1980, April

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Letter from Dr. Feingold Dear Parents: Some interesting and important events occurred during the past quarter. The FDA science symposium, “Effects of Foods and Drugs on the Development and Function of the Nervous System: Methods for Predicting Toxicity” was very … Continue reading

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Archives – FAWA 1978 December

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Letter from Dr. Feingold to the Feingold Association of the United States Greetings to All Members of FAUS, This past quarter has been very productive. Great progress has been made in public awareness, acceptance and application of the diet. This … Continue reading

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Archives – FAWA 1980, November

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The Nutrition Foundation Strikes Again We had not heard from the Nutrition Foundation for a long time. They’re the alter-ego of the American Council on Science and Health. Like ACSH, the Nutrition Foundation sounds like an unbiased, scientific pillar of … Continue reading

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Archives – FAWA 1977, September

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First FDA study supports Feingold theory Results from the first federally-sponsored study of the Feingold hypothesis are strongly supportive of a key facet of the KP diet. Following two experiments funded by the Food & Drug Administration, researchers at the … Continue reading

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Archives – FAWA 1977, November

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Dr. Feingold’s Visit Dr. Feingold addressed a standing-room-only audience of FAWA members on October 8th. Here are some of the highlights from his talk. We are no longer in the position of having to “prove” the validity of our knowledge. … Continue reading

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Archives – FAWA 1977, December

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Answering the critics FAWA Newsletter, December 1977 (page 9-10) Feingold families are often confronted by newspaper and magazine articles — some of which appear in medical journals — telling us that the KP Diet doesn’t really work. (Those sleepless nights … Continue reading

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Archives – 1982, 01/29

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Feingold diet is worth testing, panel says American Medical News (newsletter of the American Medical Association)January 29, 1982, page 23.

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Archives – 1982, 01/16

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Treating hyperactivity Houston Post January 16, 1982 Click on article to enlarge

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Archives – 1977, Aug 03

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Does what we eat affect behavior? The St. Louis Globe-Democrat, August 3, 1977

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A new collection of studies on the relationship of food dyes to health

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Just finished: a compilation of all the studies I can find on the food dyes used in the US and their connection with behavior and health. Download here (190 pages) This project was created to help the California Office of … Continue reading

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Augustine 1980: Neurotransmitter Release from a Vertebrate Neuromuscular Synapse Affected by a Food Dye

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Science. 207(4438):  1489-90. Red 3 was applied to nerve synapses in the frog, producing an irreversible, dose-dependent increase in neurotransmitter release. The author suggested this may be useful for studying neurotransmitters, but that the use of Red 3 as a … Continue reading

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El-Desoky 2017: Curcumin Protects Against Tartrazine-Mediated Oxidative Stress and Hepatotoxicity in Male Rats

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European Review for Medical & Pharmacological Sciences. (21): 635-645. Curcumin (an extract of turmeric) was studied to see if it could protect against the kidney and liver damage expected from the ADI of Tartrazine (Yellow 5) given in the diet. … Continue reading

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Al-Seeni 2018: Nigella Sativa Oil Protects Against Tartrazine Toxicity in Male Rats.

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Toxicology Reports. 5: 146-155. This was not a test of tartrazine (Yellow 5) – they already knew it would be toxic.  Rats in the “positive control” group (given Yellow 5) had elevated liver enzymes, cholesterol and triglycerides, as well as … Continue reading

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Don’t miss this free seminar series

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If you, or your child, have a tic disorder or Tourette’s Syndrome, you may feel like the disorder controls your life.   But there is hope — you can manage a tic disorder, naturally, so that you feel in control. Don’t … Continue reading

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Rodrigo 2018: Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study

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Nutrients.  May 7;10(5). pii: E573. Rodrigo says that Tourette Syndrome (GTS) and gluten sensitivity may be associated.  23 children and 6 adults were put on a gluten-free diet and followed for a year.    They found a “marked reduction” in tics, … Continue reading

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Ludlow 2018: Understanding the Impact of Diet and Nutrition on Symptoms of Tourette Syndrome: A Scoping Review

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Journal of Child Healthcare. Mar;22(1):68-83 Ludlow and Rogers want to write a review of existing studies, but actually they are stuck with anecdotal reports because so little research has been done in this area.  As they say, however, “anecdotal reports … Continue reading

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Briguglio 2018: Dietary Neurotransmitters: A Narrative Review on Current Knowledge

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Nutrients. May 10;10(5). pii: E591 Some of the many substances found in foods are neurotransmitters (NT), including acetylcholine, glutamate, GABA, dopamine, serotonin and histamine.   Not only are these neurotransmitters part of the food itself, but they may be added or … Continue reading

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Dufault 2018: Food labeling requirements may explain lower autism and ADHD prevalence in the United Kingdom

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Integrative Food, Nutrition and Metabolism, 2018, 5(4): 1-2 This editorial explores possible nutritional reasons for the huge difference between the United States and the United Kingdom in numbers of children diagnosed with ADHD or autism. After two separate studies in … Continue reading

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Li 2018: Inedible Azo Dyes and Their Analytical Methods in Foodstuffs and Beverages

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Journal of AOAC International, Vol. 101.  (epublished ahead of print) This guest editorial is not about the food dyes we know and don’t love — it’s about inedible, dangerous food dyes that are used illegally in foods.  There is a … Continue reading

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Prabhakaran 2017: Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.

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Pharmacotherapy. 2017 May;37 (5): 607-610. Albuterol in bottles used for multiple dosing contains benzalkonium chloride (BAC) as a preservative.  The authors say that many pediatric hospitals use this kind of albuterol when preparing solutions for continuous nebulized albuterol for asthma … Continue reading

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Tseng 2018: Peripheral iron levels in children with attention-deficit hyperactivity disorder: A systematic review and meta-analysis

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Scientific Reports,  2018 Jan 15;8(1):788. 17 studies on iron and ADHD were analyzed by Tseng et al in Taiwan. Iron does more than prevent anemia; besides helping in  homeostatis of the hemoglobin (red blood cell) structure, iron is important to the … Continue reading

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Leo 2018: Occurrence of Azo Food Dyes and their Effects on Cellular Inflammatory Responses

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Nutrition. 2018 February. 46:36-40 This study found that 11.54% of the 1,681 processed items examined in a local supermarket in Singapore contained at least one of five food dyes — of which tartrazine (Yellow 5), sunset yellow (Yellow 6), and … Continue reading

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Science Library Text Collection – updated

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Today I have finally listed all the “open” research studies collected up to now.  This brings the Library Text Collection up to more than 3,000 papers listed. Now to start the next part of the project — updating the list … Continue reading

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Rainbow-colored cake anybody?

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In study after study, the dangers of artificial food dyes are documented.  Nevertheless, many of us would still like to provide colorful party foods for our families.  What to do?  Of course, bright fruits such as blueberries and strawberries can … Continue reading

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Feingold 1978: Address to California School Food Service Association, Sacramento, CA

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Although this speech was given in 1978, it could equally apply today.  Tragically, his warning went unheeded, and nothing has changed. Ladies and Gentlemen: I am pleased to be with you today to discuss the importance of the School Food … Continue reading

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Choudhary 2017: Neurophysiological symptoms and aspartame: What is the connection?

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Nutritional Neuroscience, 2017 Feb 15:1-11. This is a review of studies linking neuro-physiological symptoms to aspartame usage which concludes that aspartame may be responsible for adverse neurobehavioral health outcomes. QUOTE:  “Aspartame consumption needs to be approached with caution due to … Continue reading

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