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International Journal of Antimicrobial Agents. Dec;56(6):106214. Most studies of Covid-19 involve very sick hospitalized patients. The authors are testing the use of Hydroxycholoroquine (HCQ) plus zinc and an antibiotic (for prevention of secondary lung infection) as an early treatment beginning … Continue reading
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American Journal of Tropical Medicine & Hygiene. 103(4), pp. 1635-1639 From the chart, you might think that the authors would have concluded that HCQ (Hydroxychloroquine) is a useful treatment for Covid-19, but according to their statistical analysis, they actually concluded … Continue reading
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International Journal of Antimicrobial Agents. Oct;56(4):106144. In Belgium, HCQ has been used off-label for hospitalized patients with Covid-19. The authors compared patients receiving HCQ for 5 days to patients receiving only supportive care. As can be seen in Fig. 1, … Continue reading
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European Review for Medical & Pharmacoloical Sciences. 24: 4539-4547. Using information from the WHO, ISI-Web of Knowledge, Thomson Reuter journals, PubMed, Medline, and clinical trial registries, the authors concluded their findings support the hypothesis that HCQ has efficacy in treatment … Continue reading
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British Medical Journal. 369: m1844. All the patients in this study were in various hospitals. They all needed oxygen and had developed pneumonia. An unknown number of the group given HCQ were not treated for the first two days after … Continue reading
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Journal of Global Health, 10(1). June 2020 Basically, their answer is YES. Only about 20% of patients with COVID-19 develop serious symptoms, which seem to take about a week to come on, giving time to identify those at risk and … Continue reading
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British Journal of General Practice, 2020 Jun; 4(2) This is another review of studies published by March 2020, and only 3 studies were discussed. They are listed in Table 1 in the document. Of these three studies, the one from … Continue reading
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American Journal of Ophthalmology (editorial), 2020 May; 213: A3–A4. and Aug; 216: A1–A2. This is an editorial about the concern that while the antivirals HCQ and CQ may be helpful for COVID-19, they can cause retinal damage at high dosage … Continue reading
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Clinical Pharmacology & Therapeutics. 2020 Aug;108(2):253-263 Using pharmacokinetics integrated with in vitro data, the authors are attempting to define the best dose for HCQ both for treatment and for clinical trials, while avoiding the heart QT problem of higher doses. … Continue reading
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Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14(4), 241-146. The authors reviewed two studies on humans. concluding that due to the “minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India … Continue reading
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International Journal of Rheumatic Diseases, 2020 May;23(5):613-61. This is a review of all the (few) studies on the use of HCQ and the similar CQ for COVID-19 published by March, 2020. They searched a number of databases but only found … Continue reading
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There has been a lot of controversy about the use of Hydroxychloroquine (HCQ) as a treatment of COVID-19. This is an old antiviral medication, in use for more than 60 years, and considered safe for daily use even during pregnancy, … Continue reading
