Category Archives: COVID Medications

Hasan 2022: In silico molecular docking and ADME/T analysis of Quercetin compound with its evaluation of broad-spectrum therapeutic potential against particular diseases

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Informatics in Medicine Unlocked, 29 (2022) 100894.  Hasan, Khan, Chowdhury, Khan, Moni, & Rahman This study, done in Bangladesh and Australia, compared something called “docking” ability of Quercetin with that of the usual drugs for several diseases, and found that … Continue reading

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Gerard 2021; Remdesivir and acute renal failure: A potential safety signal from disproportionality analysis of the WHO Safety Database

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Clinical Pharmacology & Therapeutics, 109 (4), April 2021 Remdesivir has been recently approved by the US FDA for emergency use for Covid although “data pertaining to its effectiveness and safety are scant.” In this study, it was determined that this … Continue reading

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Lysine for Covid-19

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Story at-a-glance Lysine is an essential amino acid that has demonstrated positive results in the treatment of COVID-19, decreasing symptoms of infection in 80% of patients by 70% in the first 48 hours. Treatment used an average dose of 2,000 … Continue reading

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Dr. Vladimir Zelenko: Interview with Dr. Mercola

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Note:  Interview actually begins at Minute 3 Story at-a-glance As early as March 2020, Dr. Vladimir Zelenko boasted a near-100% success rate treating COVID-19 patients with hydroxychloroquine (HCQ), azithromycin and zinc sulfate for five days Zelenko has now treated 3,000 … Continue reading

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Cismaru 2021: COVID-19 and antimalarials. Have we been doing it wrong all along?

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European Journal of Pharmacology, Jan 15;891:173694 The authors recommend that instead of using Hydroxychloroquine (HCQ) together with the macrolide antibiotic Azithromycin, doctors should first use HCQ and follow this with the addition of Azithromycin. The picture at right describes the … Continue reading

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Shepshelovich 2021: Concordance between the results of randomized and non-randomized interventional clinical trials assessing the efficacy of drugs for COVID-19: A cross-sectional study

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Journal of Antimicrobial Chemotherapy, 2021 Aug 12;76(9):2415-2418 Several drug treatment trials were reviewed in this paper, including the use of Hydroxychloroquine + Azithromycin, Hydroxychloroquine alone, IL-6 Inhibitors, Corticosteroids, Convalescent Plasma, Remdesivir, and “others” including five antiretroviral drugs and two anti-influenza … Continue reading

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Formiga 2021: Ivermectin: An award-winning drug with expected antiviral activity against COVID-19

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Journal of Controlled Release, 329 (2021), 758-761. Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2  (SARS-CoV-2). In this paper, the authors discuss … Continue reading

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Khan 2020: Ivermectin treatment may improve the prognosis of patients with COVID-19

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Archivos de Bronconeumologia, 2020;56(12):816–830 The authors describe a clinical study in Bangladesh, in which half of 248 patients (without underlying conditions) received standard care, while half received standard care plus ivermectin.   A 12 mg dose of ivermectin was given just … Continue reading

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Jans 2021: The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2?

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Biochemical & Biophysical Research Communications. 538 (2021). 163-172. QUOTE:  Cell culture experiments have shown robust antiviral action towards a whole range of viruses, including HIV-1, dengue, Zika and West Nile Virus, Venezuelan equine encephalitis virus, Chikungunya, pseudorabies virus, adenovirus, and … Continue reading

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Portmann-Baracco 2020: Antiviral and anti-inflammatory properties of ivermectin and its potential use in COVID-19

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Archivos de Bronconeumologia, 56(12): 831-836. This is a letter to the editor describing the experimental use of Ivermectin for Covid-19. Ivermectin is a safe and well tolerated drug often used as a single dose for parasitosis. Thus, they used a … Continue reading

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Heidary 2020: Ivermectin–A systematic review from antiviral effects to COVID-19 complementary regimen

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The Journal of Antibiotics, 73: 593-602. This is a comprehensive systematic review, summarizing the antiviral effects of ivermectin over the past 50 years. Ivermectin plays a role in several biological mechanisms; therefore it could serve as a potential candidate in … Continue reading

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Elgazzar 2020: Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic

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Preprint:  Research Square. Ivermectin was approved for animal use in 1981, and a few years later it was approved for humans for treatment of roundworm and parasites.  Drs. William Campbell and Satoshi Omura received the 2015 Nobel Prize in Physiology … Continue reading

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Abd-Elsalam 2021: Clinical study evaluating the efficacy of ivermectin in COVID-19 treatment: A randomized controlled study

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Journal of Medical Virology, Oct;93(10):5833-5838 In an effort to see if Ivermectin would be effective in patients hospitalized with Covid-19, the authors gave half of them 12 mg of the drug for 3 (three) days.   There were 82 patients in … Continue reading

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Schumann 2020: Immune-modulating drug MP1032 (Remdesivir) with SARS-CoV-2 antiviral activity in vitro: A potential multi-target approach for prevention and early intervention treatment of COVID-19

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International Journal of Molecular Sciences. 21(22):8803. This is a complex study of Remdesivir’s activity against the cytokine storm sometimes seen in cases of Covid-19. MP1032 (Remdesivir) is a reactive-oxygen scavenger (ROS) and was originally being developed to treat psoriasis, rheumatoid … Continue reading

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Kory 2021: Review of the emerging evidence demonstrating the efficacy of Ivermectin in the prophylaxis and treatment of COVID-19

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American Journal of Therapeutics 28, e2999-e318 This is a meta-analysis of 18 randomized controlled treatment trials of ivermectin for COVID-19. CONCLUSIONS:  The meta-analysis found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, … Continue reading

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Caruso 2020: Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic

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Medical Hypotheses.  144(2020) 109910. Caruso et al reviewed 26 published studies on the use of Hydrogen Peroxide (H2O2) against viruses, considering its possible use when transmission has first happened, and the H2O2 may be able to enhance the innate immune … Continue reading

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Brownstein 2020: A novel approach to treating COVID-19 using nutritional and oxidative therapies

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Science, Public Health Policy, and the Law, Volume 2: 4-22. July 2020 Of 107 patients diagnosed with COVID-19 were given individualized treatments of Vitamin A,  Vitamin C, Vitamin D, Iodine, Nebulized and/or IV Hydrogen Peroxide, intramuscular therapies, IV Vitamin C, … Continue reading

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Derwand 2020: COVID-19 outpatients: Early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: A retrospective case series study

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International Journal of Antimicrobial Agents. Dec;56(6):106214. Most studies of Covid-19 involve very sick hospitalized patients. The authors are testing the use of Hydroxycholoroquine (HCQ) plus zinc and an antibiotic (for prevention of secondary lung infection) as an early treatment beginning … Continue reading

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Abd-Elsalam 2020: Hydroxychloroquine in the treatment of COVID-19: A multicenter randomized controlled study

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American Journal of Tropical Medicine & Hygiene. 103(4), pp. 1635-1639 From the chart, you might think that the authors would  have concluded that HCQ (Hydroxychloroquine) is a useful treatment for Covid-19, but according to their statistical analysis, they actually concluded … Continue reading

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What About Colostrum?

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All mammals nurse their young, feeding them milk produced in their mammary glands. Before the “true” milk itself is produced, however, another fluid called colostrum is provided. It is rich in nutrients as well as various growth factors; it is … Continue reading

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Catteau 2020: Low-dose hydroxychloroquine therapy and mortality in hospitalised patients with COVID-19: A nationwide observational study of 8075 participants. 

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International Journal of Antimicrobial Agents. Oct;56(4):106144. In Belgium, HCQ has been used off-label for hospitalized patients with Covid-19.  The authors compared patients receiving HCQ for 5 days to patients receiving only supportive care. As can be seen in Fig. 1, … Continue reading

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Meo 2020: Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

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European Review for Medical & Pharmacoloical Sciences. 24: 4539-4547. Using information from the WHO, ISI-Web of Knowledge, Thomson Reuter journals, PubMed, Medline, and clinical trial registries, the authors concluded their findings support the hypothesis that HCQ has efficacy in treatment … Continue reading

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Mahevas 2020: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: Observational comparative study using routine care data

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British Medical Journal.  369: m1844. All the patients in this study were in various hospitals. They all needed oxygen and had developed pneumonia.  An unknown number of the group given HCQ were not treated for the first two days after … Continue reading

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Giammaria 2020: Can early treatment of patients with risk factors contribute to managing the COVID-19 pandemic?

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Journal of Global Health, 10(1). June 2020 Basically, their answer is YES. Only about 20% of patients with COVID-19 develop serious symptoms, which seem to take about a week to come on, giving time to identify those at risk and … Continue reading

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Gbinigie 2020: Should chloroquine & hydroxychloroquine be used to treat COVID-19? A rapid review

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British Journal of General Practice, 2020 Jun; 4(2) This is another review of studies published by March 2020, and only 3 studies were discussed. They are listed in Table 1 in the document. Of these three studies, the one from … Continue reading

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Marmor 2020: COVID-19 and Chloroquine/Hydroxychloroquine: Is there ophthalmological concern?

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American Journal of Ophthalmology (editorial), 2020 May; 213: A3–A4. and Aug; 216: A1–A2. This is an editorial about the concern that while the antivirals HCQ and CQ may be helpful for COVID-19, they can cause retinal damage at high dosage … Continue reading

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Garcia-Cremades 2020: Full text Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing

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Clinical Pharmacology & Therapeutics. 2020 Aug;108(2):253-263 Using pharmacokinetics integrated with in vitro data, the authors are attempting to define the best dose for HCQ both for treatment and for clinical trials, while avoiding the heart QT problem of higher doses. … Continue reading

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Singh 2020: Chloroquine & hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search & a narrative review with a special reference to India & other developing countries.

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Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14(4), 241-146. The authors reviewed two studies on humans. concluding that due to the “minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India … Continue reading

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Shah 2020: A systematic review of the prophylactic role of chloroquine & hydroxychloroquine in coronavirus disease-19 (COVID-19)

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International Journal of Rheumatic Diseases, 2020 May;23(5):613-61. This is a review of all the (few) studies on the use of HCQ and the similar CQ for COVID-19 published by March, 2020. They searched a number of databases but only found … Continue reading

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HCQ — the Good, the Bad, & the Ugly

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There has been a lot of controversy about the use of Hydroxychloroquine (HCQ) as a treatment of COVID-19. This is an old antiviral medication, in use for more than 60 years, and considered safe for daily use even during pregnancy, … Continue reading

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