Category Archives: ADHD

Stevenson 2014: Research review: the role of diet in the treatment of attention-deficit/hyperactivity disorder–an appraisal of the evidence on efficacy and recommendations on the design of future studies.

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Journal of Child Psychology & Psychiatry, 2014 May;55(5):416-27. The author compares 3 kinds of studies for treatment of ADHD – restricted elimination diets (RED), artificial food colour elimination (AFCE), and essential fatty acid (e.g. fish oil) supplements (SFFA).  He concludes … Continue reading →

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Verlaet 2014: Nutrition, immunological mechanisms and dietary immunomodulation in ADHD.

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European Child & Adolescent Psychiatry, 2014 Jul;23(7):519-29. Verlaet discusses the common causes of GI problems, asthma, eczema, ear infections, and ADHD – involving both genes, immunity, and inflammation.  An immune imbalance can be related to food provoking ADHD-like behavior.  Food … Continue reading →

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Gray 2013: Salicylate elimination diets in children: Is food restriction supported by the evidence?

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The Medical Journal of Australia, 2013. Jun 17; 198(11): 600-2. Gray, Mehr, Katelaris … & Ziegler Gray was treating patients who had tried the low-salicylate diet (called the FAILSAFE diet) used in Australia, which is more restrictive than the Feingold diet, … Continue reading →

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Sonuga-Barke 2013: Nonpharmacological Interventions for ADHD: Systematic Review and Meta-Analyses of Randomized Controlled Trials of Dietary and Psychological Treatments

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American Journal of Psychiatry, 2013.  March. 170(3): 275-89. This paper is a review of dietary and psychological treatments for ADHD. QUOTE (Conclusion):  “Free fatty acid supplementation and artificial food color exclusions appear to have beneficial effects on ADHD symptoms, although … Continue reading →

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Stevens 2013: Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children

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Nutrition Review, 2013 May;71(5):268-81. Stevens reviews the research on mechanisms by which food dyes and common foods may cause behavioral changes in children with and without ADHD.  The three potential mechanisms are toxicological, antinutritional, and hypersensitivity. Suggestions for future studies … Continue reading →

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Arnold 2012: Artificial food colors and attention-deficit/hyperactivity symptoms: Conclusions to dye for

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Neurotherapeutics. 2012 Jul;9(3):599-609. Arnold reviews the history of the effects of artificial food colors (AFC) on ADHD and the testimony to the 2011 FDA Food Advisory Committee. Arnold discusses possible biological mechanisms such as the effects of food dyes on … Continue reading →

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Millichap 2012: The diet factor in attention-deficit/hyperactivity disorder

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Pediatrics, 2012 Feb;129(2): 330-7. Millichap says his article is a comprehensive overview of the role of diet for treatment of children with ADHD “when pharmacotherapy has proven unsatisfactory or unacceptable.”  He promises to talk about new research. Unfortunately, he falls … Continue reading →

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Saab 2012: The effect of diet supplementation on children with ADHD

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Lebanese American University, Masters Thesis 2012 In a project for her Masters Degree in Education, Linda Saab performed a case study on a 9 year old boy in Beirut who was diagnosed with ADHD.   Although he was observed for 5 … Continue reading →

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Weiss 2012: Synthetic Food Colors and Neurobehavioral Hazards: The View from Environmental Health Research

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Environmental Health Perspectives, 2012 Jan;120(1):1-5. Dr. Weiss examines the basis of the FDA’s position on food dyes, the decision of the Food Advisory Committee, and the reasons that this is an environmental health issue He points out that they limited … Continue reading →

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Hoekstra 2011: Is there potential for the treatment of children with ADHD beyond psychostimulants?

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European Child & Adolescent Psychiatry, 2011. 20 (9), 431-2. Concerned about the enormous increase in use of psychostimulant drugs such as Ritalin, the authors of this editorial discuss the research supporting the use of other options.  In particular, they find … Continue reading →

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Kamel 2011: The Potential Health Hazard of Tartrazine and Levels of Hyperactivity, Anxiety-Like Symptoms, Depression and Anti-social behaviour in Rats

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Journal of American Science, 2011; 7 (6): 1211-1218. This paper from Egypt describes a double-blind controlled study on rats to determine the behavioral effects of long-term exposure to various doses of tartrazine (E102, Yellow 5) provided in the drinking water … Continue reading →

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Pelsser 2011: Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial

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The Lancet, 2011. Feb 5;377 (9764): 494-503 This is a study of 100 children diagnosed with ADHD but not selected on any basis of expectation of a dietary effect.   The children were randomly assigned to an experimental diet group and … Continue reading →

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Stevens 2011: Dietary sensitivities and ADHD symptoms: thirty-five years of research

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Clinical Pediatrics (Phila), 2011. Apr; 50(4): 279-93. In their review of the literature, Stevens et al conclude that the evidence indicates that a diet free of food dyes is appropriate for “children who have not responded satisfactorily to conventional treatment, … Continue reading →

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Pelsser 2010: Effects of food on physical and sleep complaints in children with ADHD: a randomised controlled pilot study

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European Journal of Pediatrics, 2010 Sep;169(9): 1129-38. The 27 children in the Pelsser 2009 study were also evaluated for the effect of their diet condition on their sleep problems and other physical complaints.  Such complaints included headaches, bellyaches, unusual thirst, … Continue reading →

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Stevenson 2010: The Role of Histamine Degradation Gene Polymorphisms in Moderating the Effects of Food Additives on Children’s ADHD Symptoms

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American Journal of Psychiatry. 2010 Sep;167(9): 1108-15 Stevenson analyzed the reactions of children in the McCann (2007) study to see why not all children react to additives in the same way.  He found that variation in several genes that control … Continue reading →

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Pelsser 2009: A randomised controlled trial into the effects of food on ADHD

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European Child & Adolescent Psychiatry. 2009 Jan;18(1):12-9. In a randomized controlled trial in the Netherlands, 27 children were assigned either to an elimination diet or to a “waiting list” control group for 5 weeks, beginning after a 2-week “baseline” diet … Continue reading →

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Curtis 2008 Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review

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Journal of Alternative and Complementary Medicine, 2008.  Jan-Feb; 14(1): 79-85.  Curtis & Patel This is a review of literature available in 2008. The authors say many of the studies link exposure to toxins such as mercury, lead, and pesticides, as well … Continue reading →

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McCann 2007: Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial

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Lancet, September 6, 2007 As a followup to the earlier Bateman (2004) study, the authors retested 153  toddlers as well as 144 elementary school (8/9 years old) children from the general population.   They were briefly put on a dye-free … Continue reading →

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Lien 2006: Consumption of soft drinks and hyperactivity, mental distress, and conduct problems among adolescents in Oslo, Norway

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American Journal of Public Health, 2006. Oct;96(10):1815-20 The authors surveyed almost 5,500 students in 10th grade to see how many sugar-containing soft drinks they consumed per day and to assess their mental health and conduct. AUTHORS’ CONCLUSIONS:  “High consumption levels … Continue reading →

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Niederhofer 2006: A preliminary investigation of ADHD symptoms in persons with celiac disease

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Journal of Attention Disorders, 2006. Nov;10(2):200-4. Because several studies had reported a possible association of celiac disease (CD) and ADHD symptoms, the authors evaluated 132 participants diagnosed with CD – both children and adults – for ADHD symptoms before they … Continue reading →

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Bateman 2004: The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children

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Archives of Disease in Childhood. 2004 Jun;89(6):506-11. The authors put 277  3-year-old children from the general population on a diet without artificial food dyes or benzoate preservatives for a week, and then challenged them at various times with a drink … Continue reading →

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Schab 2004: Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials

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Journal of Developmental and Behavioral Pediatrics, 2004 Dec;25(6):423-34. Searching 10 databases for double-blind placebo-controlled trials on the effects of artificial food dyes, Schab and Trinh found 15 that met their criteria. QUOTE:  “Our meta-analysis supports the hypothesis that AFCs (artificial … Continue reading →

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Dengate 2002: Controlled trial of cumulative behavioural effects of a common bread preservative

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Journal of Paediatrics and Child Health, 2002. Aug;38(4):373-6.  Dengate & Ruben In Australia, 27 children whose behavior had improved on the Royal Prince Alfred Hospital diet were enrolled in a double-blind placebo-controlled test of the bread preservative calcium propionate (preservative … Continue reading →

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Pelsser 2002: Favourable effect of a standard elimination diet on the behavior of young children with attention deficit hyperactivity disorder (ADHD): a pilot study

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Nederlandsch tijdschrift voor geneeskunde 2002, Dec 28;146(52):2543-7. 36 boys and 4 girls, diagnosed with ADHD, were put on an oligoantigenic (few foods – rice, turkey, pear and lettuce) diet for two weeks.  9 children (23%) withdrew from the study because of … Continue reading →

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Starobrat-Hermelin 1998:   The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders

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Annales Academiae Medicae Stetinensis, 1998;44:297-314 Deficiencies of magnesium, copper, zinc, calcium, and iron occur more in children with ADHD, and magnesium deficiency is the most frequent.   Starobrat-Hermelin studied a group of 110 hyperactive children who also had a variety … Continue reading →

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Schmidt 1997: Does oligoantigenic diet influence hyperactive/conduct-disordered children–a controlled trial

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European Child & Adolescent Psychiatry, 1997. Jun;6(2):88-95. Fig. 1 Study design Schmidt compared the effectiveness of an oligoantigenic (few foods) diet with Ritalin for hyperactive disruptive children (today called conduct disorder).   44% responded to Ritalin while 24% responded equally well … Continue reading →

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Uhlig 1997: Topographic mapping of brain electrical activity in children with food-induced attention deficit hyperkinetic disorder

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European Journal of Pediatrics, 1997. Jul;156(7):557-61. Uhlig carried out EEG brain mapping on 15 children with food-induced ADHD, both when they were on their diet and when they had been given provoking foods. Consuming the provoking foods caused a significant … Continue reading →

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Boris 1994: Foods and Additives are Common Causes of the Attention Deficit Hyperactive Disorder in Children

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Annals of Allergy, May 1994, Vol. 72, pp. 462-8. Boris, Mandel 73% of 26 children with ADHD responded favorably to a diet eliminating reactive foods and artificial colors. 16 of the improved children were given a double blind challenge with … Continue reading →

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Rowe 1994: Synthetic Food Coloring and Behavior: A Dose Response Effect in a Double-Blind, Placebo-Controlled, Repeated-Measures Study

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Journal of Pediatrics, November 1994, Vol. 135, pp.691-8 150 of 200 children [75%] improved on an open trial of a diet free of synthetic food coloring, and deteriorated upon introduction of foods containing synthetic colorings. 34 other “clear” or “suspected” … Continue reading →

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Carter 1993: Effects of a Few Foods Diet in Attention Deficit Disorder

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Archives of Disease in Childhood, November 1993, Vol. 69 (5), pp.564-8 Carter, Urbanowicz, Hemsley, & Taylor 59 of 78 children (75.6%) referred for “hyperactive behavior” improved on an open trial of an elimination diet.  19 of them were studied in a placebo-controlled … Continue reading →

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Egger 1992: Effect of diet treatment on enuresis in children with migraine or hyperkinetic behavior

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Clinical Pediatrics (Phila) 1992 May;31(5):302-7. 21 children with migraine and/or hyperkinetic behavior disorder also had daytime or nighttime enuresis (wetting).  Use of an oligoantigenic (few-foods) diet controlled their migraine and/or hyperkinesis, and for 76% of them the diet also stopped … Continue reading →

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Novembre 1992: Unusual reactions to food additives

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Pediatria Medica e Chirurgica 1992 Jan-Feb;14(1):39-42 The author describes two cases of reactions to the food additives tartrazine (Yellow 5) and benzoates involving mainly the central nervous system (headache, migraine, overactivity, concentration and learning difficulties, depression) and joints (arthralgias), confirmed … Continue reading →

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Schoenthaler 1991: Applied Nutrition and Behavior

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Journal of Applied Nutrition, November 1, 1991, Vol. 43. In a review of diet changes made in 813 prisons in California, implementation of “nutrient dense diets” resulted in “significantly improved conduct, intelligence, and/or academic performance” Full Text || Get Password

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Pollock 1990: Effect of artificial food colours on childhood behaviour

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Pollock & Warner, Archives of Disease in Childhood, 1990.  Jan;65(1):74-7, Heart and Lung Institute, Brompton Hospital, London. Pollock did a double-blind placebo-controlled challenge study on 19 children who had improved previously on an additive-free diet.   He didn’t use any additives … Continue reading →

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Sarantinos 1990: Synthetic Food Colouring and Behavioural Change in Children with Attention Deficit Disorder: A Double-Blind, Placebo Controlled, Repeated Measures Study

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Proceedings of the Nutrition Society of Australia, 1990 pg. 233. Sarantinos studied 13 children,  4-14 years old, who had been at least 6 weeks on a diet free of synthetic food dyes as part of their treatment for ADHD.  The … Continue reading →

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Ward 1990: The influence of the chemical additive tartrazine on the zinc status of hyperactive children: A double-blind placebo-controlled study

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Journal of Nutritional Medicine; 1 (1). 1990. 51-58. Ward first studied the zinc status in various tissues (blood, hair, saliva, etc) in 20 hyperactive boys compared to 20 non-hyperactive boys.  Then, in a double-blind placebo-controlled study of 10 hyperactive boys … Continue reading →

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Egger 1989: Oligoantigenic diet treatment of children with epilepsy and migraine

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Journal of Pediatrics, 1989. Jan;114(1):51-8. Egger, Carter, Soothill, & Wilson Egger put 45 children with epilepsy and recurrent headaches, abdominal symptoms, or hyperactivity on an oligoantigenic (few foods) diet.   36 of them — 80% — improved. QUOTE:  “Headaches, abdominal pains, … Continue reading →

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Kaplan 1989: Overall Nutrient Intake of Preschool Hyperactive and Normal Boys

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Journal of Abnormal Child Psychology, April 1989, Vol. 17(2), pp.127-32. Kaplan compared food diaries of children with and without ADHD and concluded that it was idiosyncratic sensitivities to components in the diet rather than a different overall diet. MedLine || … Continue reading →

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Rowe 1988: Synthetic Food Colourings and “Hyperactivity”: a Double-Blind Crossover Study

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Australian Paediatric Journal, April 1988, Vol. 24 (2), pp. 143-7 Of 220 children referred for suspected hyperactivity, 55 were put on a 6-week trial of the Feingold Diet.    40 of them — 72.7% — exhibited improved behavior, and 26 of … Continue reading →

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Burlton-Bennett 1987: A Single Subject Evaluation of the K-P Diet for Hyperkinesis

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Journal of Learning Disabilities, 1987 Jun-Jul;20(6):331-5, 346. Burlton-Bennett & Robinson A single subject ABAB (on-off-on-off) design was used to test the effectiveness of the Feingold (K-P) diet in the treatment of a 6-year-old hyperkinetic male who seemed to  be diet-responsive.  … Continue reading →

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David 1987: Reactions to dietary tartrazine

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Archives of Disease in Childhood, 1987. Feb;62(2):119-22. In a double-blind study, David challenged 24 of his patients who had been using diet for ADHD with benzoic acid (a preservative) and a large dose of coloring — 250 mg of Yellow … Continue reading →

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Gross 1987: The effect of diets rich in and free from additives on the behavior of children with hyperkinetic and learning disorders

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Journal of the American Academy of Child and Adolescent Psychiatry. 1987. Jan;26(1):53-5. Gross carried out a diet study in a summer camp which is a great way to totally control the diet and get solid results in a study. NOTE:  … Continue reading →

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Schoenthaler 1986: The Impact of a Low Food Additive and Sucrose Diet on Academic Performance in 803 New York City Public Schools

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International Journal for Biosocial Research, 1986, 8(2); 185-195. Over 4 years, 803 New York City schools changed their breakfast and lunch programs.  They lowered sucrose, synthetic food color/flavors, and two preservatives (BHA and BHT). For each change, there was an … Continue reading →

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Egger 1985: Controlled Trial of Oligoantigenic Treatment in the Hyperkinetic Syndrome

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The Lancet, 9;1(8428):540-5.  Egger, Carter, Graham, Gumley, & Soothill 62 of 76  (81.6%) overactive children improved by at least one grade level on an oligoantigenic (few foods) diet.  Benzoic acid and tartrazine (Yellow 5) were the most common problems, but all … Continue reading →

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Menzies 1984: Disturbed children: the role of food and chemical sensitivities

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Nutrition and Health. 1984; 3(1-2): 39-54. Menzies reviews the existing literature and presents a number of case studies of children with idiosyncratic responses to foods and additives. QUOTE:  “Perhaps not enough attention has been paid to the role of biological … Continue reading →

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Egger 1983: Is migraine food allergy? A double-blind controlled trial of oligoantigenic diet treatment

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Lancet, 1983. Oct 15;2(8355):865-9.  Egger, Carter, Wilson, Turner, & Soothill 93% of 88 children with severe frequent migraine recovered on an oligoantigenic (few foods) diet.  40 of them were challenged with various foods in a double-blind test, establishing that it … Continue reading →

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Mattes 1983: The Feingold diet: a current reappraisal

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Journal of Learning Disabilities, 1983.  Jun-Jul;16(6):319-23. Mattes gives his opinion that improvement on the Feingold diet is  “based on anecdotal evidence;” he claims that the studies show the diet “is probably not effective, except perhaps in a very small percentage … Continue reading →

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Feingold 1982: The role of diet in behaviour

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Ecology of Disease, 1982. 1(2-3):153-65 QUOTE:The increase in behavioural disorders accompanied by a persistent drop in scholastic performance coupled with the continuing rise in the prevalence of delinquency is undoubtedly one of the most important expressions of the disruption of … Continue reading →

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Goldenring 1982: Sulfanilic acid: behavioral change related to azo food dyes in developing rats

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Neurobehavioral Toxicology and Teratology, 1982. Jan-Feb;4(1): 43-9. Goldenring, Batter & Shaywitz Goldenring studied the effects of giving sulfanilic acid to rat pups.  He chose this chemical because it is formed when azo food dyes are digested.  He gave the sulfanilic acid … Continue reading →

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Salamy 1982: Physiological changes in hyperactive children following the ingestion of food additives

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International Journal of Neuroscience, 1982. May;16(3-4):241-246 QUOTE:  “… The physiological measures [EEG and heart rate] were obtained prior to and following the ingestion of drinks containing food additives or placebos, which were administered in a double-blind, randomized, crossover procedure. … … Continue reading →

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Mattes 1981: Effects of artificial food colorings in children with hyperactive symptoms. A critical review and results of a controlled study

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Mattes & Gittelman, Archives of General Psychiatry. 1981. June; 38(6): 714-8 Mattes claimed he tried to maximize the behavioral effects of artificial food dyes by (1) studying only children already on the Feingold diet,  (2) trying to exclude placebo responders, … Continue reading →

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Swanson 1980: Food Dyes Impair Performance of Hyperactive Children on a Laboratory Learning Test

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Science, March 28, 1980, Vol. 207. pp.1485-7 QUOTE:  “The performance of the hyperactive children on paired-associate learning tests on the day they received the dye blend was impaired relative to their performance after they received the placebo, but the performance … Continue reading →

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Weiss 1980: Behavioral responses to artificial food colors

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Science, 1980. March 28;207 (4438): 1487-9. QUOTE:  ”Twenty-two young children, maintained on a diet that excluded certain foods, were challenged intermittently with a blend of seven artificial colors in a double-blind trial. Parents’ observations provided the criteria of response. One … Continue reading →

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Brenner 1979: Trace mineral levels in hyperactive children responding to the Feingold diet

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The Journal of Pediatrics. 1979. June; 94(6):944-5 Trying to find a reason why some children respond well to the Feingold Diet and others don’t, Brenner measured copper and zinc levels in the blood of 20 children who had responded well … Continue reading →

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Feingold 1979: Dietary management of juvenile delinquency

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International Journal of Offender Therapy and Comparative Criminology, 1979. Vol 23(1) 73-84. QUOTE:  “This disenchantment with present-day rehabilitation techniques prompted the Ford Foundation in its annual report for 1977 to recommend that the role in delinquency of biochemical and organic … Continue reading →

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Lafferman 1979: Erythrosin B inhibits dopamine transport in rat caudate synaptosomes.

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Science. 1979. July 27; 205 (4404): 410-2. Lafferman found that erythrosin B [Red 3] given to rats prevents the uptake of dopamine (the “feel good” neurotransmitter) by nerve cells in the brain called the caudate synaptosomes.  This is consistent with … Continue reading →

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Shaywitz 1979: Effects of chronic administration of food colorings on activity levels and cognitive performance in developing rat pups treated with 6-hydroxydopamine

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Neurobehavioral Toxicology, 1979.  Spring;1(1):41-7.  (Today called Neurotoxicology and Teratology) In a study on rat pups, the highest dose of food dyes caused the greatest activity.  Even after a half hour, the pups only calmed down by 7.25% — while the … Continue reading →

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Dumbrell 1978: Is the Australian version of the Feingold diet safe?

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Medical Journal of Australia, 1978 Dec 2;2(12):548, 569-70. Dumbrell, Woodhill, Mackie & Leelarthaepin The Feingold diet, as used in Australia, was found to be nutritionally superior to a “normal” diet, and pronounced safe to use. MedLine

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Fitzsimon 1978: Salicylate sensitivity in children reported to respond to salicylate exclusion

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Medical Journal of Australia, 1978. Dec 2;2(12):570-2. Fitzsion, Holborow, Berry & Latham To test for reactions to salicylate, 12 children who had been on the Feingold diet for about a year were challenge-tested with 40 mg of acetylsalicylic acid (aspirin) in … Continue reading →

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Goyette 1978: Effects of artificial colors on hyperkinetic children: a double-blind challenge study

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Psychopharmacology Bulletin, 1978. April;  14(2):39-40.    Goyette, Conners, Petti, & Curtis Goyette et al performed two studies: Experiment One:  16 children were put on the diet and were much improved according to both parents and teachers.  Then they were challenged … Continue reading →

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