Category Archives: COVID-19

Covid-19 vaccine & Microvascular Injury

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Back in December, 2020, before the vaccine rollout was well underway, Dr. J. Patrick Whelan of UCLA sent a warning to the FDA (see it below).  They duly posted it at their website, but otherwise appear to have ignored it. … Continue reading

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Derwand 2020: COVID-19 outpatients: Early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: A retrospective case series study

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International Journal of Antimicrobial Agents. Dec;56(6):106214. Most studies of Covid-19 involve very sick hospitalized patients. The authors are testing the use of Hydroxycholoroquine (HCQ) plus zinc and an antibiotic (for prevention of secondary lung infection) as an early treatment beginning … Continue reading

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Abd-Elsalam 2020: Hydroxychloroquine in the treatment of COVID-19: a multicenter randomized controlled study

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American Journal of Tropical Medicine & Hygiene. 103(4), pp. 1635-1639 From the chart, you might think that the authors would  have concluded that HCQ (Hydroxychloroquine) is a useful treatment for Covid-19, but according to their statistical analysis, they actually concluded … Continue reading

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What About Colostrum?

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All mammals nurse their young, feeding them milk produced in their mammary glands. Before the “true” milk itself is produced, however, another fluid called colostrum is provided. It is rich in nutrients as well as various growth factors; it is … Continue reading

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Catteau 2020: Low-dose hydroxychloroquine therapy and mortality in hospitalised patients with COVID-19: A nationwide observational study of 8075 participants. 

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International Journal of Antimicrobial Agents. Oct;56(4):106144. In Belgium, HCQ has been used off-label for hospitalized patients with Covid-19.  The authors compared patients receiving HCQ for 5 days to patients receiving only supportive care. As can be seen in Fig. 1, … Continue reading

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Meo 2020: Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

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European Review for Medical & Pharmacoloical Sciences. 24: 4539-4547. Using information from the WHO, ISI-Web of Knowledge, Thomson Reuter journals, PubMed, Medline, and clinical trial registries, the authors concluded their findings support the hypothesis that HCQ has efficacy in treatment … Continue reading

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Mahevas 2020: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: Observational comparative study using routine care data

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British Medical Journal.  369: m1844. All the patients in this study were in various hospitals. They all needed oxygen and had developed pneumonia.  An unknown number of the group given HCQ were not treated for the first two days after … Continue reading

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Giammaria 2020: Can early treatment of patients with risk factors contribute to managing the COVID-19 pandemic?

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Journal of Global Health, 10(1). June 2020 Basically, their answer is YES. Only about 20% of patients with COVID-19 develop serious symptoms, which seem to take about a week to come on, giving time to identify those at risk and … Continue reading

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Gbinigie 2020: Should chloroquine & hydroxychloroquine be used to treat COVID-19? A rapid review

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British Journal of General Practice, 2020 Jun; 4(2) This is another review of studies published by March 2020, and only 3 studies were discussed. They are listed in Table 1 in the document. Of these three studies, the one from … Continue reading

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Marmor 2020: COVID-19 and Chloroquine/Hydroxychloroquine: Is there ophthalmological concern?

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American Journal of Ophthalmology (editorial), 2020 May; 213: A3–A4. and Aug; 216: A1–A2. This is an editorial about the concern that while the antivirals HCQ and CQ may be helpful for COVID-19, they can cause retinal damage at high dosage … Continue reading

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Garcia-Cremades 2020: Full text Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing

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Clinical Pharmacology & Therapeutics. 2020 Aug;108(2):253-263 Using pharmacokinetics integrated with in vitro data, the authors are attempting to define the best dose for HCQ both for treatment and for clinical trials, while avoiding the heart QT problem of higher doses. … Continue reading

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Singh 2020: Chloroquine & hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search & a narrative review with a special reference to India & other developing countries.

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Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14(4), 241-146. The authors reviewed two studies on humans. concluding that due to the “minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India … Continue reading

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Shah 2020: A systematic review of the prophylactic role of chloroquine & hydroxychloroquine in coronavirus disease-19 (COVID-19)

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International Journal of Rheumatic Diseases, 2020 May;23(5):613-61. This is a review of all the (few) studies on the use of HCQ and the similar CQ for COVID-19 published by March, 2020. They searched a number of databases but only found … Continue reading

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HCQ — the Good, the Bad, & the Ugly

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There has been a lot of controversy about the use of Hydroxychloroquine (HCQ) as a treatment of COVID-19. This is an old antiviral medication, in use for more than 60 years, and considered safe for daily use even during pregnancy, … Continue reading

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