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The Journal of Clinical Psychiatry. 2016 Oct;77(10): e1342-e1347 Drugs used for bipolar disorder often work by down-regulating the brain metabolism of a long-chain omega-6 (or n-6) essential fatty acid called arichidonic acid (AA). The shorter-chain omega-6 (or n-6) essential fatty … Continue reading
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Otolaryngology Head & Neck Surgery. 2015 Jan; 152(1): 42-47. Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetyl-salicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment may include steroids, surgery, and/or aspirin desensitization. In this study of 10 patients, … Continue reading
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International Forum of Allergy & Rhinology. 2016. April; 6(4): 385-91 30 patients diagnosed with aspirin sensitivity and aspirin-exacerbated respiratory disease (AERD) were entered into a diet trial. They ate either a regular diet or a low-salicylate diet for 6 … Continue reading
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Acta Otorhinolaryngologica Belgica. 1995;49(3): 235-50. In this review of aspirin-sensitive rhinosinusitis, it is described as a non-allergic, non-infectious perennial eosinophilic rhinitis starting in middle age and rarely seen in children. It may also been seen in atopic patients who have … Continue reading
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Childs Nervous System. 2011 May;27(5): 793-802 This is one of the first studies to investigate the relationship between dietary components and Tourette syndrome (TS). Using the laboratory that tested the Olympic Games contestants for illegal stimulant drugs, the researchers tested … Continue reading
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Mutation Research. 2002 Aug 26; 519(1-2): 103-19. Sasaki et al, in Japan, tested 39 common food additives — dyes, color fixatives, preservatives, antioxidants, fungicides, and sweeteners. They gave each additive separately by mouth to groups of four male mice, and … Continue reading
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Annals of General Psychiatry (2015) March 1; 14:12 This was a study on children with ADHD who were already receiving Ritalin therapy, to see if improving their diet in general might make a difference. The children were divided into two … Continue reading
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Journal of Food Science. 2013 April; 78(4): T642-7 This is the first national study on food additive use in India, collecting data on “sweets and savories.” Their dye extraction and identification technique (using pure wool strands) is described, as is … Continue reading
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Journal of Attention Disorders, Vol. 3(1): 30-48 (1999) This review of “alternative” treatments was undertaken for the National Institute of Health (NIH) 1998 Consensus Development Conference on ADHD. 23 such treatments were identified. Some were considered effective or possibly effective … Continue reading
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Journal of the American Academy of Child and Adolescent Psychiatry. 2012 Jan; 51(1): 86–97.e8. This meta-analysis of 24 published studies on food colors, plus 10 more on dietary restriction, concluded that a restriction diet (e.g., the Feingold diet or an … Continue reading
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Pediatric Nursing. 2007 Mar-Apr; 33(2): 138-43. This review is intended to help nurses support parents who want to try various therapeutic diets such as the Feingold diet, oligoantigenic (few foods) diet, or gluten-free, casein-free diet for their children. The nurses … Continue reading
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Journal of Paediatrics and Child Health. 1997 June; 33(3): 190-4. The author summarizes and discusses the research from the 1970s up until the 1990s. She emphasizes that studies often only can deal with a single item but in actuality there … Continue reading
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Applied Psychophysiology and Biofeedback, 2003 March; 28(1): 63-75. In this paper, Schnoll reviews the research on food additives, refined sugars, food allergies, and fatty acid metabolism as it relates to ADHD. QUOTE: “Although clinicians and researchers alike acknowledge the complex … Continue reading
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Roczniki Panstwowego Zakladu Higieny. 2012;63(2): 127-34 In this review of ADHD treatments, Konikowska describes hyperactivity as a genetic trait connected to abnormal brain maturation, likely related to less activity by neurotransmitters dopamine and norepinephrine. While stimulant medications effectively increase the … Continue reading
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Scientific Reports, 2016 Jan 5;6:18989. Air pollution is good for something …. if you are a pigeon racer. It seems that in northern China, homing pigeons fly home lots faster through polluted air. The authors say it isn’t yet clear … Continue reading
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The Journal of Toxicological Sciences, Vol. 37, No. 6, 1247-1252. 2012 By studying the brains of mice whose mothers were exposed to titanium dioxide (TiO2) nanoparticles during pregnancy, the researchers determined changes in gene expression affecting several parts of the … Continue reading
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Scientific Reports, 2016 March 31;6:23819 The purpose of this study was to better understand how the widely used titanium dioxide may impact the environment. The researchers used swallowtail butterfly larvae which were hatched on plants growing in water containing titanium … Continue reading
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Acupuncture & Electro-Therapeutics Research., Vol. 40, pp. 157-187, 2015 Omura reports on a non-invasive method developed to detect neurotransmitters, bacteria, metals, virus, and other abnormal molecules using an electromagnetic field resonance phenomenon through the pupil of the eye. The researchers … Continue reading
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Environmental Monitoring and Assessment. (2016) 188:575 This Swiss study looks at the effect of two kinds of nanoparticles, separately and combined. Both copper oxide (CuO) and titanium dioxide (TiO2) ultrafine particles (nanoparticles or NP) are widely used in many things … Continue reading
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Nanotoxicology. 2016 Sep;10(7):902-12. In this study, 25 µg/L and 250 µg/L of the food color additive titanium dioxide (TiO2) nanoparticles were added to outdoor mesocosms* placed in a lake. The control mesocosm was not treated with any TiO2. * A … Continue reading
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Journal of Biomedical Materials Research Part A. 2014 Feb; 102(2): 470-8. Titanium dioxide is a naturally occurring white powder approved by the FDA. It is used as a white coloring in many products we use every day such as toothpaste, … Continue reading
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The New Microbiologica, 2016. July ;39(3): 228-231. Endogenous Retroviruses in humans (HERVs) are derived from ancient viral infections which over time became part of the usual human genome. In fact, they make up 8% of the total genome (98,000 fragments, … Continue reading
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The Australian and New Zealand Journal of Psychiatry. 2016 Sep 30. doi: 10.1177/0004867416670013 The researchers analyzed the records of 1,233 infants, whose parents filled out an ADHD questionnaire when the child was a little less than 3 years old. They … Continue reading
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Toxicology and Industrial Health, 2013. March; 29(2): 224-32. doi: 10.1177/0748233711433935 The researchers wanted to evaluate the toxic effect of some synthetic colorants and/or flavors on body organs and metabolism in rats. They used 10 groups of 10 male albino rats … Continue reading
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Journal of Allergy and Clinical Immunology, 2000 Mar;105(3):462-7 In this study, a questionnaire was filled out by 366 adult asthma patients. Over 33% of them said that their asthma had been triggered by alcohol at least twice, with wine reported … Continue reading
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Schweizerische medizinische Wochenschrift (Swiss medical weekly), 1981. Sep 26; 111(39): 1445-50 Wuthrich wrote that adverse reactions to aspirin, additives such as tartrazine (Yellow 5) and the preservative benzoate are seen all over the world. It is described as an intolerance … Continue reading
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Journal of Allergy & Clinical Immunology, 1979 Dec;64(6 Pt 1):500-6 In this study, a positive response was defined as a 20% fall in forced expiratory volume in 1 second (FEV1) for up to 4 hours. The researchers tested several hundred … Continue reading
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Tohoku Journal of Experimental Medicine, 1979. Nov; 129(3): 303-9. In this study on guinea pigs, the researchers showed that the dye Yellow 5 potentiates asthmatic reactions to other broncho-constrictors. In other words, the dye may not cause an asthma attack … Continue reading
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Prenatal Diagnosis. 2016, Sep 29. doi: 10.1002/pd.4932 Edlow reviews the current animal and human research showing a connection between maternal (and sometimes paternal) obesity and high fat diets on neuro-developmental and psychiatric disorders in the offspring. These disorders include cognitive … Continue reading
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Life Sciences. 1980 Nov 17;27(20):1897-904. In this study, some rats were treated with 6-OHDA and some were treated with placebo. In each of these groups, some were given food dyes and some were given placebo, resulting in 4 groups of … Continue reading
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Toxicology International. 2015 Jan-Apr; 22(1): 152–157. This study was done to see if the common food colors tartrazine (Yellow 5), metanil yellow (a non-permitted color often used illegally) and sunset yellow (Yellow 6) may play a part in liver disease. … Continue reading
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Journal of Attention Disorders. 2010 Jun 23. In Norway, the Prescription Database contains information on all prescription drugs dispensed since 2001, which creates a unique opportunity to address the issue of whether the diagnoses of ADHD and asthma are associated … Continue reading
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Journal of Clinical Epidemiology, 1995. Oct;48(10):1269-75 Corder estimated safe doses to use for epidemiological studies by studying reactions of patients in an allergy clinic. He said that reactions to the four compounds listed in the table are common, and may … Continue reading
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British Journal of Dermatology, 2008. Dec;159(6):1368-9. This is a case report of several patients with disabling salicylate-induced intolerance including severe urticaria, asthma, and anaphylactic reactions. After dietary supplementation with 10 g daily of fish oils rich in omega-3 for 6-8 … Continue reading
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The Journal of Allergy & Clinical Immunology, 113(2), Suppl, S32 Both Levalbuterol (LEV) and racemic Albuterol (RAC) are bronchodilator medications used for asthma, but parents complain that children are more restless and hyperactive after taking LEV. In this study, attention … Continue reading
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International Journal of Environmental Research and Public Health, 2016 July 4;13(7). pii: E678. In this study of Taiwanese children, a strong correlation was found between amount of sugar-sweetened beverages (SSB) consumed per day and ADHD. A dose-response effect was observed, … Continue reading
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Annual Review of Public Health, 2015 Mar 18;36:211-30. The objective of this review is to provide an overview on the population impact of toxins on the developing brain and describe implications for public health. QUOTE: “The blood–brain barrier of the … Continue reading
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Physiology & Behavior, 135 (2014), 174-179. SULT1A inhibitors in foods, including natural substances and artificial food colors, have a role in ADHD that can both worsen or improve symptoms. … SULT1A inhibition can influence brain catecholamines through the intermediary of … Continue reading
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Clinical Allergy. 1978 Jan;8(1): 65-8. In an Israeli hospital, Neuman et al tested the effect of 50 mg of tartrazine (Yellow 5) on 97 patients with a variety of allergic disorders and 25 with non-allergic rhinitis. First, all patients were … Continue reading
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Cell Metabolism, 2016 July 12;24(1): 75-90 Both flies and mice have the same pathways which are triggered by sucralose (Splenda) to make the body think it is starving and increase the desire to eat. Wang explains that a sweet taste … Continue reading
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Little Debbie Swiss Rolls Use Yellow, Red, and Blue Dyes to Make ‘Chocolate’ Cake Reprinted from article published by the Center for Science in the Public Interest, July 18, 2016 Little Debbie Swiss Rolls have a combined 32 milligrams of … Continue reading
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Environmental Health Perspectives, 2012. Jul;120(7): 935-43. In this study, the authors measured chemicals in cosmetics, personal care products, cleaners, sunscreens, and vinyl products, to determine what they contain in the way of asthma-causing chemicals and endocrine disruptors (chemicals that mess up … Continue reading
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Prostaglandins and Medicine, 1978 Dec;1(6):499-505 The authors discuss the bronchoconstriction caused by tartrazine (Yellow 5) in people who are aspirin-sensitive, as well as its effect on the prostaglandin system of guinea pig lungs. They found that the dye inhibits formation … Continue reading
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Annals of Allergy, 1977. Mar;38(3): 206-10 In this paper, Lockey describes the battery of tests he had developed to determine sensitivity to food additives and analgesics, which he says can make symptoms of asthma and chronic urticaria (hives) worse. MedLine … Continue reading
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Annals of Allergy 1977 Jul;39(1):28-37 This is an early review of the combination of asthma, nasal pathology and intolerance to aspirin as a “unique syndrome” with a tendency for diabetes as well as a prolongation of bleeding time. Abrishami mentions … Continue reading
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Clinical Allergy. 1976 Mar;6(2): 119-29. In this study, Stenius and Lemola used far less of tartrazine (Yellow 5) and aspirin than what a person may normally ingest, and had to overcome chronic medication as well (see NOTES below). Nevertheless, they … Continue reading
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Journal of Allergy and Clinical Immunology, 1975. Sep;56(3): 215-21 The authors presented their evidence that in aspirin intolerance there are two mechanisms – one causing bronchospasm (breathing difficulty such as in asthma) and the other causing urticaria (hives). They also … Continue reading
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International Journal of Nursing Studies, 2005 Feb;42(2):229-41 In this review, it is noted that deficiencies in cholesterol, tryptophan (an amino acid), protein, iron, or zinc are each connected to an increase in aggression as well as cognitive and behavior problems. … Continue reading
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British Journal of Psychiatry (2002), 181,22–28 This was a double-blind, placebo-controlled, randomised study of 231 young adult prisoners. They were given nutritional supplements used in England, and their disciplinary offenses before and after were compared. QUOTE: “Conclusions: Antisocial behaviour … Continue reading
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Pharmacological Research, 1999. Sep;40 (3):211-25 DHA and EPA are long-chain omega-3 fatty acids. This review lists the many benefits of these as well as the effects of a deficiency in both infants and adults. QUOTE: “… deficiencies of DHA are … Continue reading
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Integrative Physiological and Behavioral Science, 1998, Jan-Mar;33(1):49-60 This was a small study of 17 children, some on medications and some not. During the study, some of those on medication had their meds reduced by half and some did not. For … Continue reading
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Physiology & Behavior 2015, Jan. 138:179-87. This is a small study showing that autism is both genetic and environmental. The more “bad” microbes in the gut, the worse the autism, and probiotics helped. QUOTE: “This pilot study suggests the role … Continue reading
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Alternative Therapies in Health and Medicine, 2015. 21 Suppl 1:52-62. During the past 50 years, the amount of synthetic dye used in foods has increased by 500%. At the same time, there has been an alarming rise in behavioral problems … Continue reading
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Clinical Pediatrics, 2016 Oct; 55(12): 1113-1119. In this study, 810 products commonly marketed to children and found in a local grocery store were evaluated. 43.2% of them contained artificial food colors (AFC), mostly Red 40, Blue 1, Yellow 5, and … Continue reading
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Acta Alimentaria, 43(2), 344-359. QUOTE: “Given that it is now well-known that autistic patients tend to be PST-deficient, causal link between a low-salicylate diet and the mitigation of symptom-severity seems a rather plausible hypothesis.” QUOTE: “It is quite apparent from … Continue reading
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Clinical Pediatrics, 2015 Apr;54(4):309-21, e-published April 24, 2014 Numerous foods and candies were purchased from local stores and processed to measure the amount of food dyes actually in them. Several comprehensive tables provide the details, but below is a sample: Some … Continue reading
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Clinical Pediatrics, 2014. Feb; 53(2): 133-40. The amount of food dyes certified over the years has increased more than 5-fold since 1950 (12 mg/capita/day) to 2012 (68 mg/capita/day). Studies that used 50 mg or more of food dyes showed a … Continue reading
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Journal of Child Psychology & Psychiatry, 2014 May;55(5):416-27. The author compares 3 kinds of studies for treatment of ADHD – restricted elimination diets (RED), artificial food colour elimination (AFCE), and essential fatty acid (e.g. fish oil) supplements (SFFA). He concludes … Continue reading
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European Child & Adolescent Psychiatry, 2014 Jul;23(7):519-29. Verlaet discusses the common causes of GI problems, asthma, eczema, ear infections, and ADHD – involving both genes, immunity, and inflammation. An immune imbalance can be related to food provoking ADHD-like behavior. Food … Continue reading
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Eastern Michigan University Master’s Theses. 2013. Bell counted number of exposures to food dye, not the actual amounts of dye, consumed, and she found that children are exposed to food dyes at least twice as much as adults. She also … Continue reading
